Conversion of antimalarial drug artemisinin to a new series of tricyclic 1,2,4-trioxanes

被引：15

作者：

Singh, Chandan ^{[1
]}

Chaudhary, Sandeep ^{[1
]}

Kanchan, Rani ^{[1
]}

Puri, Sunil K. ^{[1
]}

机构：

[1] Cent Drug Res Inst, Div Med & Proc Chem, Div Parasitol, Lucknow 226001, Uttar Pradesh, India

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 21期

关键词：

D O I：

10.1021/ol701887x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient route for the conversion of the antimalarial drug artemisinin to a novel hydroxy-functionalized tricyclic 1,2,4-triaxane 6 is reported. Neither the trioxane 6 nor its derivatives 14-16, all of which lack the hydrolytically unstable acetal-lactone linkage, show antimalarial activity comparable with that of artemisinin.

引用

页码：4327 / 4329

页数：3

共 20 条

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