The basic chemistry of nitrogen monoxide and peroxynitrite

被引：285
作者：
Koppenol, WH [1 ]
机构：
[1] ETH Zurich, Anorgan Chem Lab, CH-8092 Zurich, Switzerland
来源：
FREE RADICAL BIOLOGY AND MEDICINE | 1998年 / 25卷 / 4-5期
关键词：
nitrogen monoxide; peroxynitrite; kinetics; thermodynamics; reduction potential; superoxide dismutase; review;
D O I：
10.1016/S0891-5849(98)00093-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
After a discussion of the physical chemistry of nitrogen monoxide, such as solubility (1.55 mM at 37 degrees C and an ionic strength of 0.15 M) and diffusion constant (4.8 x 10(-5) cm(2)s(-1)), several reactions that can acts as sinks are discussed, namely the reaction with dioxygen, with thiols and with superoxide. Of these, the latter reaction leads to a powerful oxidant, peroxynitrite. The thermodynamic and kinetic properties of this molecule are also reviewed. (C) 1998 Elsevier Science Inc.
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收藏
页码：385 / 391
页数：7
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