Microwave-Accelerated Cross-Dehydrogenative Coupling of Quinoxalin-2(1H)-ones with Alkanes under Transition-Metal-Free Conditions

被引：6

作者：

Wang, Min ^{[1
,2
]}

Zhang, Zhongyi ^{[2
]}

Xiong, Chunxia ^{[2
]}

Sun, Peipei ^{[1
]}

Zhou, Chao ^{[2
]}

机构：

[1] Nanjing Normal Univ, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Nanjing 210023, Peoples R China

[2] Huaibei Normal Univ, Minist Educ, Key Lab Green & Precise Synthet Chem & Applicat, Huaibei 235000, Anhui, Peoples R China

来源：

CHEMISTRYSELECT | 2022年 / 7卷 / 22期

基金：

中国国家自然科学基金;

关键词：

Microwave irradiation; Cross-dehydrogenative coupling; BPO; Alkanes; Quinoxalin-2(1H)-ones; CYCLOBUTANONE OXIME ESTERS; VISIBLE-LIGHT PHOTOREDOX; C-H ARYLATION; QUINOXALINONE DERIVATIVES; DECARBOXYLATIVE C3-DIFLUOROARYLMETHYLATION; ALKYLATION; PHOTOCATALYST; HETEROCYCLES; AMINATION; DESIGN;

D O I：

10.1002/slct.202200816

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

With simple alkanes as the alkyl radical precursors under microwave irradiation, a convenient and efficient cross-dehydrogenative alkylation reaction of quinoxalin-2(1H)-ones and other N-heteroarenes has been achieved. The protocol demonstrates a broad substrate scope, good functional group tolerance, high atom economy and high efficiency, providing a wide range of valuable, structurally diverse C3 alkylated quinoxalin-2(1H)-ones and other alkylated N-heteroarenes in good-to-excellent yields.

引用

页数：6

共 113 条

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[2]

[Anonymous], 2008, ANGEW CHEM, V120, P6374

[3]

[Anonymous], 2014, ANGEW CHEM, V126, P76

[4] β-Nitroacrylates as Key Starting Materials for the Uncatalysed One-Pot Synthesis of Polyfunctionalized Dihydroquinoxalinone Derivatives, via an anti-Michael Reaction [J].