Isolation of drugs from biological fluids by using pH sensitive poly(acrylic acid) grafted poly(vinylidene fluoride) polymer membrane in vitro

被引：9

作者：

Karppi, Jouni

Akerman, Satu

Akerman, Kari

Sundell, Annika

Nyyssonen, Kristlina

Penttila, Kka

机构：

[1] Kuopio Univ Hosp, Lab Ctr, Kuopio, Finland

[2] Univ Kuopio, Publ Hlth Res Inst, Kuopio, Finland

[3] Kajaanin I Apteekki, Kajaani, Finland

[4] Kainuu Cent Hosp, Lab Dept, Kajaani, Finland

[5] Abo Akad Univ, Dept Polymer Technol, Turku, Finland

[6] Kuopio Res Inst Exercise Med, Kuopio, Finland

来源：

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2007年 / 67卷 / 02期

关键词：

charge; electrostatic interactions; isolation; lipophilicity; PDVF-PAA; serum;

D O I：

10.1016/j.ejpb.2007.03.014

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Isolation of acidic and basic model drugs by using pH sensitive poly(acrylic acid) grafted poly(vinylidene fluoride) (PAA-PVDF) cation-exchange membrane from biological fluids was reported. Effects of drug charge and lipophilicity on adsorption were also investigated. In the present study, basic model drugs adsorbed to a considerably greater extent onto the membrane than acidic drugs. Albumin was not adsorbed onto the membrane. Results of our study exposed, that electrostatic interactions between positively charged basic drug and negatively charged PVDF-PAA membrane were the most important factor affecting drug adsorption onto the membrane. Adsorption of acidic and basic drugs onto the PVDF-PAA membrane was not related to drug lipophilicity. The results of present study demonstrated that basic drugs adsorbed extensively onto the membrane, but albumin did not, proposing that PAA-PVDF membrane may be suitable for isolating basic drugs from proteinaceous biological fluids (i.e. serum) for subsequent monitoring and evaluation. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：562 / 568

页数：7