Multidrug-Resistant Escherichia coli Strain Isolated from Swine in China Harbors mcr-3.1 on a Plasmid of the IncX1 Type That Cotransfers with mcr-1.1

被引：5

作者：

Sun, Dewei ^{[1
,2
]}

Jin, Shanshan ^{[1
,2
]}

Wang, Jing ^{[1
,2
]}

Wang, Zhenyu ^{[1
,2
]}

Fan, Jiajian ^{[1
,2
]}

Xu, Zhengzhong ^{[1
,2
]}

Xu, Yaohui ^{[3
]}

Chen, Xiang ^{[1
,2
]}

Jiao, Xin'an ^{[1
,2
]}

机构：

[1] Yangzhou Univ, Jiangsu Coinnovat Ctr Prevent & Control Important, Jiangsu Key Lab Zoonosis, Yangzhou, Jiangsu, Peoples R China

[2] Yangzhou Univ, Minist Agr & Rural Affairs, Key Lab Prevent & Control Biol Hazard Factors Ani, Yangzhou, Jiangsu, Peoples R China

[3] Henan Univ Anim Husb & Econ, Coll Vet Med, Zhengzhou, Henan, Peoples R China

来源：

FOODBORNE PATHOGENS AND DISEASE | 2020年 / 17卷 / 10期

关键词：

swine; multidrug resistance; colistin; mcr-3; 1; InX1; plasmid; mcr-1; INFECTIONS;

D O I：

10.1089/fpd.2019.2769

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

An Escherichia coli strain isolated from the feces of swine at a pork slaughterhouse in Henan province China was found to possess two colistin-resistance genes, mcr-1 and mcr-3, plus 16 additional resistance genes. Genes mcr-1.1 and mcr-3.1 were identified on IncHI2 and IncX1 type plasmids, respectively. Transconjugants (containing mcr-3, mcr-1&mcr-3) were obtained that were 64- and 512-fold higher than the minimum inhibitory concentration of colistin on the recipient bacteria (E. coli C600), respectively. The IncX1 plasmid containing mcr-3.1 displayed a very specific structure compared with previous mcr-3. Variable and stable regions were similar across different plasmids, multiple insertion sequences and transposases.

引用

页码：597 / 601

页数：5

共 12 条

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