Multidrug-Resistant Escherichia coli Strain Isolated from Swine in China Harbors mcr-3.1 on a Plasmid of the IncX1 Type That Cotransfers with mcr-1.1

被引：5
作者：
Sun, Dewei [1 ,2 ]
Jin, Shanshan [1 ,2 ]
Wang, Jing [1 ,2 ]
Wang, Zhenyu [1 ,2 ]
Fan, Jiajian [1 ,2 ]
Xu, Zhengzhong [1 ,2 ]
Xu, Yaohui [3 ]
Chen, Xiang [1 ,2 ]
Jiao, Xin'an [1 ,2 ]
机构：
[1] Yangzhou Univ, Jiangsu Coinnovat Ctr Prevent & Control Important, Jiangsu Key Lab Zoonosis, Yangzhou, Jiangsu, Peoples R China
[2] Yangzhou Univ, Minist Agr & Rural Affairs, Key Lab Prevent & Control Biol Hazard Factors Ani, Yangzhou, Jiangsu, Peoples R China
[3] Henan Univ Anim Husb & Econ, Coll Vet Med, Zhengzhou, Henan, Peoples R China
来源：
FOODBORNE PATHOGENS AND DISEASE | 2020年 / 17卷 / 10期
关键词：
swine; multidrug resistance; colistin; mcr-3; 1; InX1; plasmid; mcr-1; INFECTIONS;
D O I：
10.1089/fpd.2019.2769
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
An Escherichia coli strain isolated from the feces of swine at a pork slaughterhouse in Henan province China was found to possess two colistin-resistance genes, mcr-1 and mcr-3, plus 16 additional resistance genes. Genes mcr-1.1 and mcr-3.1 were identified on IncHI2 and IncX1 type plasmids, respectively. Transconjugants (containing mcr-3, mcr-1&mcr-3) were obtained that were 64- and 512-fold higher than the minimum inhibitory concentration of colistin on the recipient bacteria (E. coli C600), respectively. The IncX1 plasmid containing mcr-3.1 displayed a very specific structure compared with previous mcr-3. Variable and stable regions were similar across different plasmids, multiple insertion sequences and transposases.
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收藏
页码：597 / 601
页数：5
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