Inflammasomes and Colorectal Cancer

被引：24

作者：

Shahbaz, Sanaz Keshavarz ^{[1
]}

Koushki, Khadijeh ^{[2
]}

Ayati, Seyed Hassan ^{[3
]}

Bland, Abigail R. ^{[4
]}

Bersonov, Evgeny E. ^{[5
]}

Sahebkar, Amirhossein ^{[6
,7
,8
,9
]}

机构：

[1] Qazvin Univ Med Sci, Cellular & Mol Res Ctr, Res Inst Prevent Noncommunicable Dis, Qazvin 3419759811, Iran

[2] Mashhad Univ Med Sci, Sch Med, Dept Immunol, Mashhad 9177948564, Razavi Khorasan, Iran

[3] Mashhad Univ Med Sci, Immunol Res Ctr, Sch Med, Immunobiochem Lab, Mashhad 9177948564, Razavi Khorasan, Iran

[4] Univ Otago, Sch Biomed Sci, Dept Pharmacol & Toxicol, Dunedin 9016, New Zealand

[5] Inst Gen Pathol & Pathophysiol, Lab Angiopathol, 8 Baltiiskaya St, Moscow 125315, Russia

[6] Mashhad Univ Med Sci, Biotechnol Res Ctr, Pharmaceut Technol Inst, Mashhad 9177948564, Razavi Khorasan, Iran

[7] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad 1313199137, Razavi Khorasan, Iran

[8] Univ Western Australia, Sch Med, Perth, WA 6009, Australia

[9] Mashhad Univ Med Sci, Sch Pharm, Mashhad 9177948564, Razavi Khorasan, Iran

来源：

CELLS | 2021年 / 10卷 / 09期

基金：

俄罗斯科学基金会;

关键词：

cancer; inflammation; inflammasome; pyroptosis; colorectal cancer; INFLAMMATORY-BOWEL-DISEASE; EPITHELIAL-MESENCHYMAL TRANSITION; INNATE IMMUNE RECEPTORS; NF-KAPPA-B; NLRP3; INFLAMMASOME; CROHNS-DISEASE; ULCERATIVE-COLITIS; INTESTINAL INFLAMMATION; PHAGOSOME MATURATION; SELF-RENEWAL;

D O I：

10.3390/cells10092172

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Inflammasomes are important intracellular multiprotein signaling complexes that modulate the activation of caspase-1 and induce levels of the proinflammatory cytokines interleukin-1 beta (IL-1 beta) and IL-18 in response to pathogenic microorganisms and molecules that originated from host proteins. Inflammasomes play contradictory roles in the development of inflammation-induced cancers. Based on several findings, inflammasomes can initiate and promote carcinogenesis. On the contrary, inflammasomes also exhibit anticancer effects by triggering pyroptosis and immunoregulatory functions. Herein, we review extant studies delving into different functions of inflammasomes in colorectal cancer development.

引用

页数：22

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