MicroRNA-Based Biomarkers in the Diagnosis and Monitoring of Therapeutic Response in Patients with Depression

被引:26
作者
Xu, Ya-Yun [1 ,2 ,3 ,4 ]
Xia, Qian-Hui [5 ]
Xia, Qing-Rong [1 ,3 ,4 ]
Zhang, Xu-Lai [6 ,7 ]
Liang, Jun [1 ,3 ,4 ]
机构
[1] Hefei Fourth Peoples Hosp, Dept Pharm, 316 Huangshan Rd, Hefei 230000, Anhui, Peoples R China
[2] Univ Sci & Technol China, CAS Key Lab Brain Funct & Dis, Hefei 230022, Anhui, Peoples R China
[3] Anhui Mental Hlth Ctr, Dept Psychopharmacol, Hefei 230000, Anhui, Peoples R China
[4] Anhui Med Univ, Affiliated Psychol Hosp, Dept Clin Pharm, Hefei 230000, Anhui, Peoples R China
[5] Wannan Med Coll, Sch Pharm, Wuhu 241002, Peoples R China
[6] Hefei Fourth Peoples Hosp, Dept Geriatr Psychol, 316 Huangshan Rd, Hefei 230000, Anhui, Peoples R China
[7] Anhui Med Univ, Clin Sch Mental Hlth, Hefei 230000, Anhui, Peoples R China
关键词
depression; microRNA; biomarker; diagnosis; therapy; MESSENGER-RNA EXPRESSION; BLOOD MONONUCLEAR-CELLS; MAJOR DEPRESSION; ANTIDEPRESSANT RESPONSE; CIRCULATING MICRORNAS; SEROTONIN TRANSPORTER; NEUROTROPHIC FACTOR; PREFRONTAL CORTEX; GENE-EXPRESSION; DRUG-NAIVE;
D O I
10.2147/NDT.S237116
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Depression is a debilitating mental illness that affects up to 120 million people worldwide; it is currently determined based on subjective diagnostic schemes that are limited by high uncertainty. Hence, there is an urgent need to identify effective and reliable biomarkers to increase diagnostic accuracy. MicroRNAs (miRNAs) constitute a recently discovered class of non-coding RNAs that play a key role in the regulation of gene expression by modulating translation, messenger RNA (mRNA) degradation, or stability of mRNA targets. Dysregulated expression of miRNAs is being investigated as a clinical biomarker for a variety of diseases, including depression. Accumulating evidence has shown that miRNAs participate in many aspects of neural plasticity, neurogenesis, and the stress response. This is supported by more direct studies based on human postmortem brain tissue that strongly indicate that miRNAs not only play a key role in the pathogenesis of major depressive disorder, but also present potential for the development of therapeutic targets. miRNAs in the peripheral and central nervous system are being considered as potential biomarkers in the diagnosis of depression and in monitoring the therapeutic response to antidepressants, owing to their stability, tissue-specificity, and disease-specific expression. In this review, we focus on various miRNAs in tissues and fluids that could be employed as diagnostic and therapeutic biomarkers in patients with depression.
引用
收藏
页码:3583 / 3597
页数:15
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