Changes in anti-HLA antibody titers more than 1 year after desensitization therapy with rituximab in living-donor kidney transplantation

被引：12

作者：

Takagi, Toshio ^{[1
]}

Ishida, Hideki ^{[1
]}

Shirakawa, Hiroki ^{[1
]}

Shimizu, Tomokazu ^{[1
]}

Tanabe, Kazunari ^{[1
]}

机构：

[1] Tokyo Womens Med Univ, Dept Urol, Tokyo, Japan

来源：

TRANSPLANT IMMUNOLOGY | 2010年 / 23卷 / 04期

关键词：

Low-dose rituximab; Kidney transplantation; Desensitization; RENAL-TRANSPLANTATION; ACUTE REJECTION; GLOBULIN;

D O I：

10.1016/j.trim.2010.06.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

One hundred sixty-five kidney transplantations were performed from January 2005 to December 2007 at our hospital. Low-dose rituximab was administered to 78 patients as an induction immunosuppressant. Of the 78, 48 were donor-specific anti-HLA antibodies (DSA)-positive, and the changes in the anti-HLA antibody titers could be followed up postoperatively in 35 of these patients. Anti-HLA antibodies belonging to HLA class 1 and HLA class 2 were depleted by 74% and 86%, respectively, and remained depleted for more than 2 years. Although there were no cases of graft loss, one patient suffered from chronic AMR. Thus, we could control DSA for at least a few years after kidney transplantation using rituximab as desensitization therapy. (C) 2010 Elsevier B.V. All rights reserved.

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页码：220 / 223

页数：4

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