Neurogenic orthostatic hypotension of Parkinson's disease: What exploration for what treatment?

被引：7

作者：

Senard, J. -M. ^{[1
]}

Pathak, A. ^{[1
]}

机构：

[1] Univ Toulouse, INSERM, U858, Serv Pharmacol Clin,CHU Toulouse, F-31000 Toulouse, France

来源：

REVUE NEUROLOGIQUE | 2010年 / 166卷 / 10期

关键词：

Parkinson's disease; Orthostatic hypotension; Treatment; CARDIOVASCULAR AUTONOMIC RESPONSES; MULTIPLE-SYSTEM ATROPHY; ATHEROSCLEROSIS RISK; PREDICTS MORTALITY; DYSFUNCTION; PREVALENCE; DENERVATION; SILDENAFIL;

D O I：

10.1016/j.neurol.2010.07.007

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The aim of this short review is to illustrate, using orthostatic hypotension as an example, the clinical problems related to autonomic features in Parkinson's disease Orthostatic hypotension is frequently encountered in Parkinson's disease and its diagnosis remains manometric (a fall of at least 20 and/or 10 mmHg in standing blood pressure) It is often associated with supine hypertension to be taken into account before prescribing. To distinguish between the role of disease and of drugs (not only antiparkinsonian drugs), a simple clinical test of autonomic nervous system activity (deep breathing test and standing test with measurement of 30/15 ratio) can be used. When diagnosis with multisystem atrophy is discussed, cardiac [I-123]-metaiodobenzylguanidine (MIBG) scintigraphy is of value showing in Parkinson's disease a decreased uptake of the radiopharmaceutical indicating postganglionic sympathetic denervation. Concerning treatment, nonpharmacological methods have to be systematically used since no drug has been specifically evaluated for the treatment of orthostatic hypotension of Parkinson's disease (C) 2010 Elsevier Masson SAS. All rights reserved

引用

页码：779 / 784

页数：6

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