Ghrelin increases intake of rewarding food in rodents

被引：265

作者：

Egecioglu, Emil ^{[1
]}

Jerlhag, Elisabet ^{[2
]}

Salome, Nicolas ^{[1
]}

Skibicka, Karolina P. ^{[1
]}

Haage, David ^{[3
]}

Bohlooly-Y, Mohammad ^{[4
]}

Andersson, Daniel ^{[2
]}

Bjursell, Mikael ^{[4
]}

Perrissoud, Daniel ^{[5
]}

Engel, Jorgen A. ^{[2
]}

Dickson, Suzanne L. ^{[1
]}

机构：

[1] Univ Gothenburg, Dept Physiol & Endocrinol, Inst Neurosci & Physiol, Sahlgrenska Acad, SE-40530 Gothenburg, Sweden

[2] Univ Gothenburg, Dept Pharmacol, Inst Neurosci & Physiol, Sahlgrenska Acad, SE-40530 Gothenburg, Sweden

[3] Umea Univ, Physiol Sect, Dept Integrat Med Biol, S-90187 Umea, Sweden

[4] AstraZeneca R&D, Molndal, Sweden

[5] AEternaZentaris, Frankfurt, Germany

来源：

ADDICTION BIOLOGY | 2010年 / 15卷 / 03期

基金：

瑞典研究理事会;

关键词：

Dopamine; food anticipation; motivation; obesity; reward; VTA; STIMULATES LOCOMOTOR-ACTIVITY; DOPAMINE-OVERFLOW; RECEPTOR; PEPTIDE; ANTAGONISTS; MECHANISM; AREAS;

D O I：

10.1111/j.1369-1600.2010.00216.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated whether ghrelin action at the level of the ventral tegmental area (VTA), a key node in the mesolimbic reward system, is important for the rewarding and motivational aspects of the consumption of rewarding/palatable food. Mice with a disrupted gene encoding the ghrelin receptor (GHS-R1A) and rats treated peripherally with a GHS-R1A antagonist both show suppressed intake of rewarding food in a free choice (chow/rewarding food) paradigm. Moreover, accumbal dopamine release induced by rewarding food was absent in GHS-R1A knockout mice. Acute bilateral intra-VTA administration of ghrelin increased 1-hour consumption of rewarding food but not standard chow. In comparison with sham rats, VTA-lesioned rats had normal intracerebroventricular ghrelin-induced chow intake, although both intake of and time spent exploring rewarding food was decreased. Finally, the ability of rewarding food to condition a place preference was suppressed by the GHS-R1A antagonist in rats. Our data support the hypothesis that central ghrelin signaling at the level of the VTA is important for the incentive value of rewarding food.

引用

页码：304 / 311

页数：8

共 27 条

[1] Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite [J].