Effects of Dietary n-3 and n-6 Polyunsaturated Fatty Acids in Inflammation and Cancerogenesis

被引：141

作者：

Liput, Kamila P. ^{[1
,2
]}

Lepczynski, Adam ^{[3
]}

Ogluszka, Magdalena ^{[1
]}

Nawrocka, Agata ^{[1
,4
]}

Polawska, Ewa ^{[1
]}

Grzesiak, Agata ^{[3
]}

Slaska, Brygida ^{[5
]}

Pareek, Chandra S. ^{[6
,7
]}

Czarnik, Urszula ^{[8
]}

Pierzchala, Mariusz ^{[1
]}

机构：

[1] Polish Acad Sci, Dept Genom & Biodivers, Inst Genet & Anim Biotechnol, Ul Postepu 36A, PL-05552 Jastrzebiec, Magdalenka, Poland

[2] Polish Acad Sci, Dept Mol Biol, Inst Genet & Anim Biotechnol, Ul Postepu 36A, PL-05552 Jastrzebiec, Magdalenka, Poland

[3] West Pomeranian Univ Technol, Dept Physiol Cytobiol & Prote, Ul K Janickiego 29, PL-71270 Szczecin, Poland

[4] Polish Acad Sci, Dept Expt Genom, Inst Genet & Anim Biotechnol, Ul Postepu 36A, PL-05552 Jastrzebiec, Magdalenka, Poland

[5] Univ Life Sci Lublin, Fac Anim Sci & Bioecon, Inst Biol Bases Anim Prod, Akad 13, PL-20950 Lublin, Poland

[6] Nicolaus Copernicus Univ, Fac Biol & Vet Sci, Inst Vet Med, Dept Basic & Preclin Sci, Ul J Gagarina 7, PL-87100 Torun, Poland

[7] Nicolaus Copernicus Univ, Ctr Modern Interdisciplinary Technol, Div Funct Genom Biol & Biomed Res, Ul Wilenska 4, PL-87100 Torun, Poland

[8] Univ Warmia & Mazury, Fac Anim Bioengn, Dept Pig Breeding, Ul M Oczapowskiego 5, PL-10719 Olsztyn, Poland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 13期

关键词：

PUFA; omega-3 fatty acids; omega-6 fatty acids; oxylipins; inflammation; cancerogenesis; TUMOR-ASSOCIATED MACROPHAGES; FISH-OIL SUPPLEMENTATION; ISCHEMIC-HEART-DISEASE; FAT-1 TRANSGENIC MICE; PROTEIN E-FABP; DOCOSAHEXAENOIC ACID; LINOLEIC-ACID; EICOSAPENTAENOIC ACID; ARACHIDONIC-ACID; IN-VITRO;

D O I：

10.3390/ijms22136965

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The dietary recommendation encourages reducing saturated fatty acids (SFA) in diet and replacing them with polyunsaturated fatty acids (PUFAs) n-3 (omega-3) and n-6 (omega-6) to decrease the risk of metabolic disturbances. Consequently, excessive n-6 PUFAs content and high n-6/n-3 ratio are found in Western-type diet. The importance of a dietary n-6/n-3 ratio to prevent chronic diseases is linked with anti-inflammatory functions of linolenic acid (ALA, 18:3n-3) and longer-chain n-3 PUFAs. Thus, this review provides an overview of the role of oxylipins derived from n-3 PUFAs and oxylipins formed from n-6 PUFAs on inflammation. Evidence of PUFAs' role in carcinogenesis was also discussed. In vitro studies, animal cancer models and epidemiological studies demonstrate that these two PUFA groups have different effects on the cell growth, proliferation and progression of neoplastic lesions.

引用

页数：25

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