Proteasomes: Destruction as a programme

被引:272
作者
Hilt, W
Wolf, DH
机构
关键词
D O I
10.1016/0968-0004(96)10012-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Proteasomes are large multi-subunit protease complexes that selectively degrade intracellular proteins. Most of the proteins removed by these proteases are tagged for destruction by ubiquitination. Proteasomes have a role to play in controlling cellular processes, such as metabolism and the cell cycle, through signal-mediated proteolysis of key enzymes and regulatory proteins. They also operate in the stress response, by removing abnormal proteins, and in the immune response, by generating antigenic peptides.
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页码:96 / 102
页数:7
相关论文
共 48 条
[1]   INTERFERON-GAMMA INDUCES DIFFERENT SUBUNIT ORGANIZATIONS AND FUNCTIONAL DIVERSITY OF PROTEASOMES [J].
AKI, M ;
SHIMBARA, N ;
TAKASHINA, M ;
AKIYAMA, K ;
KAGAWA, S ;
TAMURA, T ;
TANAHASHI, N ;
YOSHIMURA, T ;
TANAKA, K ;
ICHIHARA, A .
JOURNAL OF BIOCHEMISTRY, 1994, 115 (02) :257-269
[2]   INTERFERON-GAMMA STIMULATION MODULATES THE PROTEOLYTIC ACTIVITY AND CLEAVAGE SITE PREFERENCE OF 20S MOUSE PROTEASOMES [J].
BOES, B ;
HENGEL, H ;
RUPPERT, T ;
MULTHAUP, G ;
KOSZINOWSKI, UH ;
KLOETZEL, PM .
JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (03) :901-909
[3]   MULTIPLE UBIQUITIN-CONJUGATING ENZYMES PARTICIPATE IN THE IN-VIVO DEGRADATION OF THE YEAST MAT-ALPHA-2 REPRESSOR [J].
CHEN, P ;
JOHNSON, P ;
SOMMER, T ;
JENTSCH, S ;
HOCHSTRASSER, M .
CELL, 1993, 74 (02) :357-369
[4]   THE UBIQUITIN-PROTEASOME PROTEOLYTIC PATHWAY [J].
CIECHANOVER, A .
CELL, 1994, 79 (01) :13-21
[5]   UBIQUITINATION OF THE G(1) CYCLIN CLN2P BY A CDC34P-DEPENDENT PATHWAY [J].
DESHAIES, RJ ;
CHAU, V ;
KIRSCHNER, M .
EMBO JOURNAL, 1995, 14 (02) :303-312
[6]   SUBUNITS OF THE REGULATORY COMPLEX OF THE 26S PROTEASE [J].
DUBIEL, W ;
FERRELL, K ;
RECHSTEINER, M .
MOLECULAR BIOLOGY REPORTS, 1995, 21 (01) :27-34
[7]   MHC CLASS-I EXPRESSION IN MICE LACKING THE PROTEASOME SUBUNIT LMP-7 [J].
FEHLING, HJ ;
SWAT, W ;
LAPLACE, C ;
KUHN, R ;
RAJEWSKY, K ;
MULLER, U ;
VONBOEHMER, H .
SCIENCE, 1994, 265 (5176) :1234-1237
[8]   YEAST-CELL CYCLE PROTEIN CDC48P SHOWS FULL-LENGTH HOMOLOGY TO THE MAMMALIAN PROTEIN VCP AND IS A MEMBER OF A PROTEIN FAMILY INVOLVED IN SECRETION, PEROXISOME FORMATION, AND GENE-EXPRESSION [J].
FROHLICH, KU ;
FRIES, HW ;
RUDIGER, M ;
ERDMANN, R ;
BOTSTEIN, D ;
MECKE, D .
JOURNAL OF CELL BIOLOGY, 1991, 114 (03) :443-453
[9]   SACCHAROMYCES-CEREVISIAE 26S PROTEASE MUTANTS ARREST CELL-DIVISION IN G2/METAPHASE [J].
GHISLAIN, M ;
UDVARDY, A ;
MANN, C .
NATURE, 1993, 366 (6453) :358-362
[10]  
GLOTZER M, 1991, NATURE, V349, P132, DOI 10.1038/349132a0