Defending the end zone: Studying the players involved in protecting chromosome ends

被引：21

作者：

Chan, Suzanne S. ^{[1
]}

Chang, Sandy ^{[1
,2
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Genet, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, Houston, TX 77030 USA

来源：

FEBS LETTERS | 2010年 / 584卷 / 17期

关键词：

Telomere; Shelterin; DNA damage response; NHEJ; DNA-DAMAGE RESPONSE; ABERRANT HOMOLOGOUS RECOMBINATION; HUMAN TELOMERES; MAMMALIAN TELOMERES; DYSFUNCTIONAL TELOMERES; DYSKERATOSIS-CONGENITA; UNCAPPED TELOMERES; GENOMIC STABILITY; HUMAN RAP1; TRF2;

D O I：

10.1016/j.febslet.2010.06.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The linear nature of eukaryotic chromosomes leaves natural DNA ends susceptible to triggering DNA damage responses. Telomeres are specialized nucleoprotein structures that comprise the "end zone" of chromosomes. Besides having specialized sequences and structures, there are six resident proteins at telomeres that play prominent roles in protecting chromosome ends. In this review, we discuss this team of proteins, termed shelterin, and how it is involved in regulating DNA damage signaling, repair and replication at telomeres. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：3773 / 3778

页数：6

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