Antibacterial calcium phosphate composite cements reinforced with silver-doped magnesium phosphate (newberyite) micro-platelets

被引:14
作者
Sikder, Prabaha [1 ]
Coomar, Paritosh Perry [2 ]
Mewborn, Jacob M. [1 ]
Bhaduri, Sarit B. [1 ,3 ]
机构
[1] Univ Toledo, Dept Mech Ind & Mfg Engn, Toledo, OH 43606 USA
[2] Univ Michigan, Coll Literature Sci & Arts, Ann Arbor, MI 48109 USA
[3] Natl Sci Fdn NSF, ENG EEC Div, Alexandria, VA 22314 USA
基金
美国国家科学基金会;
关键词
Composites; Calcium phosphate cements; Antibacterial; Newberyite; Micro-platelets; BONE-CEMENT; CRACK DEFLECTION; SINGLE-PHASE; HYDROXYAPATITE; COATINGS; NANOPARTICLES; DEGRADATION; INFECTION; MECHANISM; STRATEGY;
D O I
10.1016/j.jmbbm.2020.103934
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
This article demonstrates our efforts in developing and evaluating all-ceramic, biodegradable composites of calcium phosphate cements (CPCs) reinforced with silver (Ag)-doped magnesium phosphate (MgP) crystals. Two primary goals of this study were to 1) enhance CPC's poor mechanical properties with micro-platelet reinforcement, and 2) impart antibacterial functionalities in composites with the aim to inhibit surgical site infections (SSI). The work embodies three novel features. First, as opposed to well-known reinforcements with whisker or fiber-like morphology, we explored micro-platelets for the first time as the strengthening phase in the CPC matrix. Second, in contrast to conventional polymeric or calcium phosphate (CaP) fibrous reinforcements, newberyite (NB, MgHPO4 center dot 3H(2)O) micro-platelets belonging to the less explored yet promising MgP family, were evaluated as reinforcements for the first time. Third, NB micro-platelets were doped with Ag+ ions (AgNB, Ag content: 2 wt%) for enhancing antibacterial functionalities. Results indicated that 1 wt% of AgNB micro-platelet incorporation in the CPC matrix enhanced the compressive and flexural strengths by 200% and 140% respectively as compared to the un-reinforced ones. Besides, antibacterial assays revealed effective bactericidal functionalities (>99% bacteria kill) of the AgNB reinforced CPCs against Escherichia coli. Finally, cytocompatibility studies confirmed favorable pre-osteoblast cell proliferation and differentiation in vitro. Hence, this effort was successful in developing a self-setting and injectable AgNB reinforced CPC composition with favorable mechanical and antibacterial properties.
引用
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页数:12
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