Identification of a new sildenafil analogue adulterant, desethylcarbodenafil, in a herbal supplement

被引：22

作者：

Huang, Yen-Chun ^{[1
]}

Lee, Hui-Chun ^{[2
]}

Lin, Yun-Lian ^{[3
]}

Lin, Ya-Tze ^{[2
]}

Tsai, Chia-Fen ^{[2
]}

Cheng, Hwei-Fang ^{[2
]}

机构：

[1] Super Lab Co Ltd, Chem Lab, New Taipei, Taiwan

[2] Taiwan Food & Drug Adm, Div Res & Anal, Taipei, Taiwan

[3] China Med Univ, Dept Chinese Pharmaceut Sci & Chinese Med Resourc, Taichung, Taiwan

来源：

FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT | 2016年 / 33卷 / 11期

关键词：

Sildenafil analogue; desethylcarbodenafil; adulterated food supplements; DIETARY-SUPPLEMENTS;

D O I：

10.1080/19440049.2016.1236402

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In a maca-containing herbal supplement claimed to remedy erectile dysfunction, a new sildenafil analogue was found using adulterant screening with TLC, GC-MS and LC-MS/MS. This compound was isolated by column chromatography and HPLC, and identified by extensive 1D- and 2D-NMR and mass spectral analyses. The structure of this new compound was established as 5-[2-ethoxy-5-(piperazine-1-carbonyl) phenyl]-1-methyl-3-propyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one, and was named desethylcarbodenafil.

引用

页码：1637 / 1642

页数：6

共 6 条

[1] Identification of a new sildenafil analogue in a health supplement [J].