Interferon-α2b Treatment for COVID-19

被引：245

作者：

Zhou, Qiong ^{[1
]}

Chen, Virginia ^{[2
,3
]}

Shannon, Casey P. ^{[2
,3
]}

Wei, Xiao-Shan ^{[1
]}

Xiang, Xuan ^{[1
]}

Wang, Xu ^{[1
]}

Wang, Zi-Hao ^{[1
]}

Tebbutt, Scott J. ^{[2
,3
,4
]}

Kollmann, Tobias R. ^{[5
]}

Fish, Eleanor N. ^{[6
,7
]}

机构：

[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Resp & Crit Care Med, Wuhan, Peoples R China

[2] Univ British Columbia, St Pauls Hosp, Prevent Organ Failure PROOF Ctr Excellence, Vancouver, BC, Canada

[3] Univ British Columbia, St Pauls Hosp, Ctr Heart Lung Innovat, Vancouver, BC, Canada

[4] Univ British Columbia, Dept Med, Div Resp Med, Vancouver, BC, Canada

[5] Telethon Kids Inst, Ctr Precis Hlth, Syst Vaccinol, Nedlands, WA, Australia

[6] Univ Toronto, Univ Hlth Network, Toronto Gen Hosp, Res Inst, Toronto, ON, Canada

[7] Univ Toronto, Dept Immunol, Toronto, ON, Canada

来源：

FRONTIERS IN IMMUNOLOGY | 2020年 / 11卷

关键词：

interferon; COVID-19; viral shedding; IL-6; inflammation; ARDS;

D O I：

10.3389/fimmu.2020.01061

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The global pandemic of COVID-19 cases caused by infection with SARS-CoV-2 is ongoing, with no approved antiviral intervention. We describe here the effects of treatment with interferon (IFN)-alpha 2b in a cohort of confirmed COVID-19 cases in Wuhan, China. In this uncontrolled, exploratory study, 77 adults hospitalized with confirmed COVID-19 were treated with either nebulized IFN-alpha 2b (5 mU b.i.d.), arbidol (200 mg t.i.d.) or a combination of IFN-alpha 2b plus arbidol. Serial SARS-CoV-2 testing along with hematological measurements, including cell counts, blood biochemistry and serum cytokine levels, and temperature and blood oxygen saturation levels, were recorded for each patient during their hospital stay. Treatment with IFN-alpha 2b with or without arbidol significantly reduced the duration of detectable virus in the upper respiratory tract and in parallel reduced duration of elevated blood levels for the inflammatory markers IL-6 and CRP. These findings suggest that IFN-alpha 2b should be further investigated as a therapy in COVID-19 cases.

引用

页数：6

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