Roles of cytoplasmic RNP granules in intracellular RNA localization and translational control in the Drosophila oocyte

被引:25
作者
Kato, Yasuko [1 ]
Nakamura, Akira [1 ]
机构
[1] RIKEN Ctr Dev Biol, Lab Germline Dev, Kobe, Hyogo 6500047, Japan
关键词
Drosophila; mRNA localization; P body; ribonucleoprotein; translational control; OSKAR MESSENGER-RNA; POLE CELL-FORMATION; BINDING-PROTEIN; POSTERIOR LOCALIZATION; BICAUDAL-D; ANTERIOR-POSTERIOR; AXIS DETERMINATION; HNRNPA/B HOMOLOG; REPRESSOR BRUNO; DISTINCT ROLES;
D O I
10.1111/j.1440-169X.2011.01314.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Intracellular mRNA localization and translation are ways to achieve asymmetric protein sorting in polarized cells, and they play fundamental roles in cell-fate decisions and body patterning during animal development. These processes are regulated by the interplay between cis-acting elements and trans-acting RNA-binding proteins that form and occur within a ribonucleoprotein (RNP) complex. Recent studies in the Drosophila oocyte have revealed that RNP complex assembly in the nucleus is critical for the regulation of cytoplasmic mRNA localization and translation. Furthermore, several trans-acting factors promote the reorganization of target mRNAs in the cytoplasm into higher-order RNP granules, which are often visible by light microscopy. Therefore, RNA localization and translation are likely to be coupled within these RNP granules. Notably, diverse cytoplasmic RNP granules observed in different cell types share conserved sets of proteins, suggesting they have fundamental and common cellular functions.
引用
收藏
页码:19 / 31
页数:13
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