Vitamin D Deficiency Is Associated with the Presence and Severity of Diabetic Retinopathy in Type 2 Diabetes Mellitus

被引：62

作者：

Alcubierre, Nuria ^{[1
]}

Valls, Joan ^{[2
]}

Rubinat, Esther ^{[1
,3
]}

Cao, Gonzalo ^{[4
]}

Esquerda, Aureli ^{[4
]}

Traveset, Alicia ^{[5
]}

Granado-Casas, Minerva ^{[1
]}

Jurjo, Carmen ^{[5
]}

Mauricio, Didac ^{[1
,6
,7
]}

机构：

[1] Univ Lleida, Biomed Res Inst Lleida, Lleida 25198, Spain

[2] Univ Lleida, Biostat & Epidemiol Unit, Biomed Res Inst Lleida, Lleida 25198, Spain

[3] Univ Hosp Arnau de Vilanova, Dept Endocrinol & Nutr, Lleida 25198, Spain

[4] Univ Hosp Arnau de Vilanova, Dept Lab Med, Lleida 25198, Spain

[5] Univ Hosp Arnau de Vilanova, Dept Ophthalmol, Lleida 25198, Spain

[6] Hlth Sci Res Inst, Dept Endocrinol & Nutr, Badalona 08916, Spain

[7] Univ Hosp Germans Trias & Pujol, Badalona 08916, Spain

来源：

JOURNAL OF DIABETES RESEARCH | 2015年 / 2015卷

关键词：

MICROVASCULAR COMPLICATIONS; DISEASE; PREVALENCE; RISK;

D O I：

10.1155/2015/374178

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is very few evidences on the role of vitamin D in the development of diabetic retinopathy. The aim of the current study was to explore whether there is an association of vitamin D status and diabetic retinopathy in type 2 diabetes. Two groups of patients were selected: 139 and 144 patients with and without retinopathy, respectively, as assessed by an experienced ophthalmologist. Subjects with advanced late diabetic complications were excluded to avoid confounding biases. 25-Hydroxy-vitamin D-3 (25(OH) D) concentrations and vitamin D deficiency were associated with the presence of diabetic retinopathy. Additionally, patients with more advanced stages of retinopathy (grades 2-4) had lower concentrations of 25(OH) D and were more frequently vitamin D deficient as compared with patients not carrying this eye complication. In conclusion, our study confirms the association of vitamin D deficiency with the presence and severity of diabetic retinopathy in type 2 diabetes. Further experimental and prospective studies on this issue are clearly warranted.

引用

页数：7

共 24 条

[1]

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