Intracellular calcium signals in the surround of rat visual cortex lesions

被引：11

作者：

Barmashenko, G ^{[1
]}

Eysel, UT ^{[1
]}

Mittmann, T ^{[1
]}

机构：

[1] Ruhr Univ Bochum, Dept Neurophysiol MA 4 149, D-44780 Bochum, Germany

来源：

NEUROREPORT | 2001年 / 12卷 / 14期

关键词：

AMPA/kainate; fluorescence imaging; fura-2; intracellular calcium; lesion; NMDA; slices; visual cortex;

D O I：

10.1097/00001756-200110080-00009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Focal lesions of the visual cortex induce deafferentiation, excitotoxic cell death as well as functional reorganization in the surrounding tissue. The intracellular second messenger calcium is involved in a wide range of cellular responses including excitotoxicity and functional reorganization following cortical injuries. We investigated the intracellular calcium concentration [Ca2+](i) in neurons of the visual cortex using fluorescence imaging of fura-2 signals in a slice preparation obtained from lesioned and sham-operated cortices, We observed an increase in resting and stimulus evoked [Ca2+](i) in the surround of the lesion, which were mediated by NMDA and non-NMDA ionotropic glutamate receptors. This increase in [Ca2+](i) might be an important factor for lesion-induced functional reorganization in the rat visual cortex. NeuroReport 12:3023-3028 (C) 2001 Lippincott Williams & Wilkins.

引用

页码：3023 / 3028

页数：6

共 17 条

[1] Increased receptive field size in the surround of chronic lesions in the adult cat visual cortex [J].

Eysel, UT ;

Schweigart, G .

CEREBRAL CORTEX, 1999, 9 (02) :101-109

[2]

Eysel UT, 1997, ADV NEUROL, V73, P195

[3] NEURONAL DYSFUNCTION AT THE BORDER OF FOCAL LESIONS IN CAT VISUAL-CORTEX [J].

EYSEL, UT ;

SCHMIDTKASTNER, R .

NEUROSCIENCE LETTERS, 1991, 131 (01) :45-48

[4]

Gorter JA, 1997, J NEUROSCI, V17, P6179

[5] Status epilepticus decreases glutamate receptor 2 mRNA and protein expression in hippocampal pyramidal cells before neuronal death [J].

Grooms, SY ;

Opitz, T ;

Bennett, MVL ;

Zukin, RS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (07) :3631-3636

[6]

GRYNKIEWICZ G, 1985, J BIOL CHEM, V260, P3440

[7] Increased long-term potentiation in the surround of experimentally induced focal cortical infarction [J].

Hagemann, G ;

Redecker, C ;

Neumann-Haefelin, T ;

Freund, HJ ;

Witte, OW .

ANNALS OF NEUROLOGY, 1998, 44 (02) :255-258

[8] DIFFERENCES IN CA2+ PERMEABILITY OF AMPA-TYPE GLUTAMATE-RECEPTOR CHANNELS IN NEOCORTICAL NEURONS CAUSED BY DIFFERENTIAL GLUR-B SUBUNIT EXPRESSION [J].

JONAS, P ;

RACCA, C ;

SAKMANN, B ;

SEEBURG, PH ;

MONYER, H .

NEURON, 1994, 12 (06) :1281-1289

[9] Neuroscience - Long-term potentiation - A decade of progress? [J].

Malenka, RC ;

Nicoll, RA .

SCIENCE, 1999, 285 (5435) :1870-1874

[10] LESION-INDUCED TRANSIENT SUPPRESSION OF INHIBITORY FUNCTION IN RAT NEOCORTEX IN-VITRO [J].

MITTMANN, T ;

LUHMANN, HJ ;

SCHMIDTKASTNER, R ;

EYSEL, UT ;

WEIGEL, H ;

HEINEMANN, U .

NEUROSCIENCE, 1994, 60 (04) :891-906

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