TOX and CDKN2A/B Gene Polymorphisms Are Associated with Type 2 Diabetes in Han Chinese

被引：15

作者：

Wei, Fengjiang ^{[1
]}

Cai, Chunyou ^{[1
]}

Feng, Shuzhi ^{[2
]}

Lv, Jia ^{[1
]}

Li, Shen ^{[1
]}

Chang, Baocheng ^{[3
]}

Zhang, Hong ^{[4
]}

Shi, Wentao ^{[1
]}

Han, Hongling ^{[2
]}

Ling, Chao ^{[1
]}

Yu, Ping ^{[1
]}

Chen, Yongjun ^{[4
]}

Sun, Ning ^{[2
]}

Tian, Jianli ^{[2
]}

Jiao, Hongxiao ^{[1
]}

Yang, Fuhua ^{[1
]}

Li, Mingshan ^{[1
]}

Wang, Yuhua ^{[1
]}

Zou, Lei ^{[1
]}

Su, Long ^{[4
]}

Li, Jingbo ^{[5
]}

Li, Ran ^{[2
]}

Qiu, Huina ^{[5
]}

Shi, Jingmin ^{[1
]}

Liu, Shiying ^{[2
]}

Chang, Mingqin ^{[1
]}

Lin, Jingna ^{[5
]}

Chen, Liming ^{[3
]}

Li, Wei-Dong ^{[1
]}

机构：

[1] Tianjin Med Univ, Res Ctr Basic Med Sci, Tianjin 300070, Peoples R China

[2] Tianjin Med Univ, Tianjin Gen Hosp, Tianjin 300052, Peoples R China

[3] Tianjin Med Univ, Metab Dis Hosp, Tianjin 300070, Peoples R China

[4] Tianjin Med Univ, Hosp Eye, Tianjin 300384, Peoples R China

[5] Tianjin Peoples Hosp, Dept Endocrinol, Tianjin 300191, Peoples R China

来源：

SCIENTIFIC REPORTS | 2015年 / 5卷

基金：

中国国家自然科学基金;

关键词：

GENOME-WIDE ASSOCIATION; SUSCEPTIBILITY LOCI; COMMON VARIANTS; RENAL-DISEASE; RETINOPATHY; RISK; PREVALENCE; HERITABILITY; NEPHROPATHY; POPULATION;

D O I：

10.1038/srep11900

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

To study associations between type 2 diabetes (T2DM) candidate genes and microvascular complications of diabetes (MVCDs), we performed case-control association studies for both T2DM and MVCDs in Han Chinese subjects. We recruited 1,939 unrelated Han Chinese T2DM patients and 918 individuals with normal blood glucose levels as nondiabetic controls. Among T2DM patients, 1116 have MVCDs, 266 have a history of T2DM of >10 years but never developed MVCDs. Eighty-two single-nucleotide polymorphisms (SNPs) in 54 candidate genes were genotyped. Discrete association studies were performed by the PLINK program for T2DM and MVCDs. Significant associations were found among candidate gene SNPs and T2DM, including rs1526167 of the TOX gene (allele A, P = 2.85 x 10(-9), OR = 1.44). The SNP rs10811661 of the CDKN2A/B gene was also associated with T2DM (allele T, P = 4.09 x 10(-7), OR = 1.36). When we used control patients with >10 years of T2DM history without MVCD, we found that the G allele of SNP rs1526167 of the TOX gene was associated with MVCD (nominal P = 4.33 x 10(-4)). In our study, significant associations were found between TOX and CDKN2A/B gene SNPs and T2DM. The TOX polymorphism might account for the higher risk of T2DM and the lower risk of MVCDs in the Han Chinese population.

引用

页数：9

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