Practice-changing updates in the adjuvant and metastatic setting

被引:33
作者
Puccini, Alberto [1 ]
Lenz, Heinz-Josef [1 ]
机构
[1] Univ Southern Calif, Keck Sch Med, Norris Comprehens Canc Ctr, Div Med Oncol, Suite 3456,1441 Eastlake Ave, Los Angeles, CA 90033 USA
关键词
TUMORS;
D O I
10.1038/nrclinonc.2017.185
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
2017 has been full of new discoveries that will influence the treatment of colorectal cancer. In the adjuvant setting, 3 months of chemotherapy might now be considered a new standard of care. Various other new treatments and promising biomarkers have also become available that will improve survival outcomes and the quality of life of many patients with metastatic disease.
引用
收藏
页码:77 / 78
页数:2
相关论文
共 9 条
[1]  
Aljehani M. A., 2017, JAMA SURG
[2]   Prognostic and predictive value of primary tumour side in patients with RAS wild-type metastatic colorectal cancer treated with chemotherapy and EGFR directed antibodies in six randomized trials [J].
Arnold, D. ;
Lueza, B. ;
Douillard, J. -Y. ;
Peeters, M. ;
Lenz, H. -J. ;
Venook, A. ;
Heinemann, V. ;
Van Cutsem, E. ;
Pignon, J. -P. ;
Tabernero, J. ;
Cervantes, A. ;
Ciardiello, F. .
ANNALS OF ONCOLOGY, 2017, 28 (08) :1713-1729
[3]   The consensus molecular subtypes of colorectal cancer [J].
Guinney, Justin ;
Dienstmann, Rodrigo ;
Wang, Xin ;
de Reynies, Aurelien ;
Schlicker, Andreas ;
Soneson, Charlotte ;
Marisa, Laetitia ;
Roepman, Paul ;
Nyamundanda, Gift ;
Angelino, Paolo ;
Bot, Brian M. ;
Morris, Jeffrey S. ;
Simon, Iris M. ;
Gerster, Sarah ;
Fessler, Evelyn ;
Melo, Felipe De Sousa E. ;
Missiaglia, Edoardo ;
Ramay, Hena ;
Barras, David ;
Homicsko, Krisztian ;
Maru, Dipen ;
Manyam, Ganiraju C. ;
Broom, Bradley ;
Boige, Valerie ;
Perez-Villamil, Beatriz ;
Laderas, Ted ;
Salazar, Ramon ;
Gray, Joe W. ;
Hanahan, Douglas ;
Tabernero, Josep ;
Bernards, Rene ;
Friend, Stephen H. ;
Laurent-Puig, Pierre ;
Medema, Jan Paul ;
Sadanandam, Anguraj ;
Wessels, Lodewyk ;
Delorenzi, Mauro ;
Kopetz, Scott ;
Vermeulen, Louis ;
Tejpar, Sabine .
NATURE MEDICINE, 2015, 21 (11) :1350-1356
[4]   PD-1 Blockade in Tumors with Mismatch-Repair Deficiency [J].
Le, D. T. ;
Uram, J. N. ;
Wang, H. ;
Bartlett, B. R. ;
Kemberling, H. ;
Eyring, A. D. ;
Skora, A. D. ;
Luber, B. S. ;
Azad, N. S. ;
Laheru, D. ;
Biedrzycki, B. ;
Donehower, R. C. ;
Zaheer, A. ;
Fisher, G. A. ;
Crocenzi, T. S. ;
Lee, J. J. ;
Duffy, S. M. ;
Goldberg, R. M. ;
de la Chapelle, A. ;
Koshiji, M. ;
Bhaijee, F. ;
Huebner, T. ;
Hruban, R. H. ;
Wood, L. D. ;
Cuka, N. ;
Pardoll, D. M. ;
Papadopoulos, N. ;
Kinzler, K. W. ;
Zhou, S. ;
Cornish, T. C. ;
Taube, J. M. ;
Anders, R. A. ;
Eshleman, J. R. ;
Vogelstein, B. ;
Diaz, L. A., Jr. .
NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (26) :2509-2520
[5]   Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade [J].
Le, Dung T. ;
Durham, Jennifer N. ;
Smith, Kellie N. ;
Wang, Hao ;
Bartlett, Bjarne R. ;
Aulakh, Laveet K. ;
Lu, Steve ;
Kemberling, Holly ;
Wilt, Cara ;
Luber, Brandon S. ;
Wong, Fay ;
Azad, Nilofer S. ;
Rucki, Agnieszka A. ;
Laheru, Dan ;
Donehower, Ross ;
Zaheer, Atif ;
Fisher, George A. ;
Crocenzi, Todd S. ;
Lee, James J. ;
Greten, Tim F. ;
Duffy, Austin G. ;
Ciombor, Kristen K. ;
Eyring, Aleksandra D. ;
Lam, Bao H. ;
Joe, Andrew ;
Kang, S. Peter ;
Holdhoff, Matthias ;
Danilova, Ludmila ;
Cope, Leslie ;
Meyer, Christian ;
Zhou, Shibin ;
Goldberg, Richard M. ;
Armstrong, Deborah K. ;
Bever, Katherine M. ;
Fader, Amanda N. ;
Taube, Janis ;
Housseau, Franck ;
Spetzler, David ;
Xiao, Nianqing ;
Pardoll, Drew M. ;
Papadopoulos, Nickolas ;
Kinzler, Kenneth W. ;
Eshleman, James R. ;
Vogelstein, Bert ;
Anders, Robert A. ;
Diaz, Luis A., Jr. .
SCIENCE, 2017, 357 (6349) :409-413
[6]   Impact of consensus molecular subtyping (CMS) on overall survival (OS) and progression free survival (PFS) in patients (pts) with metastatic colorectal cancer (mCRC): Analysis of CALGB/SWOG 80405 (Alliance). [J].
Lenz, Heinz -Josef ;
Ou, Fang-Shu ;
Venook, Alan P. ;
Hochster, Howard S. ;
Niedzwiecki, Donna ;
Goldberg, Richard M. ;
Mayer, Robert J. ;
Bertagnolli, Monica M. ;
Blanke, Charles David ;
Zemla, Tyler ;
Qu, Xueping ;
Innocenti, Federico ;
Kabbarah, Omar .
JOURNAL OF CLINICAL ONCOLOGY, 2017, 35
[7]   Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study [J].
Overman, Michael J. ;
McDermott, Ray ;
Leach, Joseph L. ;
Lonardi, Sara ;
Lenz, Heinz-Josef ;
Morse, Michael A. ;
Desai, Jayesh ;
Hill, Andrew ;
Axelson, Michael ;
Moss, Rebecca A. ;
Goldberg, Monica V. ;
Cao, Z. Alexander ;
Ledeine, Jean-Marie ;
Maglinte, Gregory A. ;
Kopetz, Scott ;
Andre, Thierry .
LANCET ONCOLOGY, 2017, 18 (09) :1182-1191
[8]   Prospective pooled analysis of six phase III trials investigating duration of adjuvant (adjuv) oxaliplatin-based therapy (3 vs 6 months) for patients (pts) with stage III colon cancer (CC): The IDEA (International Duration Evaluation of Adjuvant chemotherapy) collaboration [J].
Shi, Qian ;
Sobrero, Alberto F. ;
Shields, Anthony Frank ;
Yoshino, Takayuki ;
Paul, James ;
Taieb, Julien ;
Sougklakos, Ioannis ;
Kerr, Rachel ;
Labianca, Roberto ;
Meyerhardt, Jeffrey A. ;
Bonnetain, Franck ;
Watanabe, Toshiaki ;
Boukovinas, Ioannis ;
Renfro, Lindsay A. ;
Grothey, Axel ;
Niedzwiecki, Donna ;
Torri, Valter ;
Andre, Thierry ;
Sargent, Daniel J. ;
Iveson, Timothy .
JOURNAL OF CLINICAL ONCOLOGY, 2017, 35
[9]   Prognostic and Predictive Relevance of Primary Tumor Location in Patients With RAS Wild-Type Metastatic Colorectal Cancer Retrospective Analyses of the CRYSTAL and FIRE-3 Trials [J].
Tejpar, Sabine ;
Stintzing, Sebastian ;
Ciardiello, Fortunato ;
Tabernero, Josep ;
Van Cutsem, Eric ;
Beier, Frank ;
Esser, Regina ;
Lenz, Heinz-Josef ;
Heinemann, Volker .
JAMA ONCOLOGY, 2017, 3 (02) :194-201