Living near waterbodies as a proxy of cyanobacteria exposure and risk of amyotrophic lateral sclerosis: a population based case-control study

被引：16

作者：

Fiore, Maria ^{[1
,2
]}

Parisio, Roberto ^{[1
]}

Filippini, Tommaso ^{[3
]}

Mantione, Valerio ^{[1
]}

Platania, Armando ^{[1
]}

Odone, Anna ^{[5
]}

Signorelli, Carlo ^{[5
,6
]}

Pietrini, Vladimiro ^{[7
]}

Mandrioli, Jessica ^{[8
,9
]}

Teggi, Sergio ^{[10
]}

Costanzini, Sofia ^{[10
]}

Antonio, Cristaldi ^{[1
,2
]}

Zuccarello, Pietro ^{[1
,2
]}

Conti, Gea Oliveri ^{[1
,2
]}

Nicoletti, Alessandra ^{[11
]}

Zappia, Mario ^{[11
]}

Vinceti, Marco ^{[3
,4
]}

Ferrante, Margherita ^{[1
,2
]}

机构：

[1] Univ Catania, Dept Med Surg & Adv Technol GF Ingrassia, Via Santa Sofia 87, I-95123 Catania, Italy

[2] Univ Catania, Environm & Food Hyg Lab LIAA, Dept GF Ingrassia, Via Santa Sofia 87, I-95123 Catania, Italy

[3] Univ Modena & Reggio Emilia, CREAGEN Environm Genet & Nutr Epidemiol Res Ctr, Dept Biomed Metab & Neural Sci, Modena, Italy

[4] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02215 USA

[5] Univ Parma, Dept Biomed Biotechnol & Translat Sci, 14 Via Gramsci, I-43126 Parma, Italy

[6] Univ Vita Salute San Raffaele, Sch Med, 58 Via Olgettina Milano, I-20132 Milan, Italy

[7] Univ Parma, Dept Neurosci, Neurol Unit, 14 Via Gramsci, I-43126 Parma, Italy

[8] S Agostino Estense Hosp, Dept Neurosci, 1355 Via Pietro Giardini, I-41126 Modena, Italy

[9] Univ Modena & Reggio Emilia, 1355 Via Pietro Giardini, I-41126 Modena, Italy

[10] Univ Modena & Reggio Emilia, Dept Engn Enzo Ferrari, 10 Via Vivarelli, I-41125 Modena, Italy

[11] Univ Catania, Dept GF Ingrassia, Sect Neurosci, Catania, Italy

来源：

ENVIRONMENTAL RESEARCH | 2020年 / 186卷 / 186期

关键词：

Amyotrophic lateral sclerosis; Cyanotoxins; Case-control study; Epidemiology; Risk; METHYLAMINO-L-ALANINE; MOTOR-NEURON DISEASE; NEURODEGENERATIVE DISEASE; CYCAD USE; BMAA; ALS; EPIDEMIOLOGY; NEUROTOXIN; BLOOMS; CYANOTOXINS;

D O I：

10.1016/j.envres.2020.109530

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Background: Epidemiological studies highlighted the possibility that exposure to cyanotoxins leads to the development of the neurodegenerative disease amyotrophic lateral sclerosis (ALS). Methods: We devised a population-based case-control study in two Italian populations. We used residential proximity of the residence to water bodies as a measure of possible exposure to cyanotoxins. Results: Based on 703 newly-diagnosed ALS cases and 2737 controls, we calculated an ALS odds ratio (OR) of 1.41 (95% CI: 0.72-2.74) for current residence in the vicinity of water bodies, and a slightly lower estimate for historical residence (OR: 1.31; 95% CI: 0.57-2.99). Subjects <65 years and people living in the Northern Italy province of Modena had higher ORs, especially when historical residence was considered. Conclusions: Overall, despite some risk of bias due to exposure misclassification and unmeasured confounding, our results appear to support the hypothesis that cyanotoxin exposure may increase ALS risk.

引用

页数：7