Preparation and Characterization of Erythrocyte Membrane-Camouflaged Berberine Hydrochloride-Loaded Gelatin Nanoparticles

被引:25
作者
Su, Jing [1 ]
Zhang, Ran [1 ]
Lian, Yumei [1 ]
Kamal, Zul [1 ,2 ]
Cheng, Zhongyao [1 ]
Qiu, Yujiao [3 ]
Qiu, Mingfeng [1 ]
机构
[1] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China
[2] Shaheed Benazir Bhutto Univ, Dept Pharm, Sheringal Dir Upper 18000, Khyber Pakhtunk, Pakistan
[3] Solebury Sch, New Hope, PA 18938 USA
基金
中国国家自然科学基金; 上海市自然科学基金;
关键词
erythrocyte membrane; berberine hydrochloride; gelatin; nanoparticles; DRUG-DELIVERY; IN-VITRO; FOCUS;
D O I
10.3390/pharmaceutics11020093
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The discovery of a new pharmacological application of berberine hydrochloride (BH) made it more clinically valuable. However, the further development of BH was hampered by its short half-life and side effects after intravenous injection. To overcome these problems, a novel BH delivery system was developed using natural red blood cell membrane-camouflaged BH-loaded gelatin nanoparticles (RBGPs) to reduce the toxicity associated with injections and achieve sustained release. The size of the RBGPs was 260.3 +/- 4.1 nm, with an obvious core-shell structure, and the membrane proteins of the RBGPs were mostly retained. The RBGP system showed significant immune-evading capabilities and little cytotoxicity to human embryonic kidney (HEK) 293T cells and LO2 cells. Finally, RBGPs improved the sustained releasing effect of BH significantly. When the cumulative release time reached 120 h, the cumulative release rate of RBGPs was 78.42%. In brief, RBGPs hold the potential to achieve long circulation and sustained-release of BH, avoid side effects caused by high plasma concentration in common injection formulations, and broaden the clinical applications of BH.
引用
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页数:12
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