Stem Cells in Cardiovascular Regeneration: From Preservation of Endogenous Repair to Future Cardiovascular Therapies

被引：11
作者：
Templin, Christian
Kraenkel, Nicolle
Luescher, Thomas F.
Landmesser, Ulf [1 ]
机构：
[1] Univ Zurich Hosp, Ctr Cardiovasc, CH-8091 Zurich, Switzerland
来源：
CURRENT PHARMACEUTICAL DESIGN | 2011年 / 17卷 / 30期
基金：
瑞士国家科学基金会; 新加坡国家研究基金会;
关键词：
Stem cells; regenerative medicine; endothelial repair; cardiovascular disease; ENDOTHELIAL PROGENITOR CELLS; ACUTE MYOCARDIAL-INFARCTION; COLONY-STIMULATING FACTOR; BONE-MARROW-CELLS; LEFT-VENTRICULAR FUNCTION; CORONARY-ARTERY-DISEASE; ACTIVATED-RECEPTOR-GAMMA; IMPROVES CARDIAC-FUNCTION; PLACEBO-CONTROLLED TRIAL; HEPATOCYTE GROWTH-FACTOR;
D O I：
10.2174/138161211797904190
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Cardiovascular disease remains the leading cause of morbidity and mortality in the developed countries. This review summarizes current pre-clinical and clinical evidence for the potential role and mechanisms of action of stem and progenitor cells in vascular and cardiac repair and regeneration. Apart from cell transplantation strategies, approaches to maintain stem cell niche function and targeting mobilization/recruitment of specific stem/progenitor cell populations may aid in preserving vascular and cardiac function. Moreover, with the use of patient-derived induced pluripotent stem cells, the field of regenerative medicine is entering a new era. Potential applications of induced pluripotent stem cells and direct reprogrammed cells as well as recent developments in tissue engineering are discussed.
引用
收藏
页码：3280 / 3294
页数：15
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