Further evidence for a peripheral component in the enhanced antinociceptive effect of systemic morphine in mononeuropathic rats: Involvement of kappa-, but not delta-opioid receptors

被引:22
作者
Catheline, G [1 ]
Kayser, V [1 ]
Guilbaud, G [1 ]
机构
[1] INSERM, U161, UNITE RECH PHYSIOPHARMACOL SYST NERVEUX, F-75014 PARIS, FRANCE
关键词
peripheral antinociception; mononeuropathic rat; paw pressure; systemic morphine; kappa-opioid receptor antagonist; delta-opioid receptor antagonist;
D O I
10.1016/S0014-2999(96)00629-2
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The contribution of a peripheral action of morphine in the augmented antinociceptive effect of this substance was re-evaluated in a well established rat model of peripheral unilateral mononeuropathy (chronic constriction Of the common sciatic nerve), using a relatively low dose of systemic morphine (1 mg/kg i.v.) and local low doses of specific antagonists of kappa- (nor-binaltorphimine) or delta-(naltrindole) opioid receptors. Vocalization thresholds to paw pressure were used as a nociceptive test. Escalating doses of nor-binaltorphimine (10-30 mu g injected locally into the nerve injured paw) significantly and dose dependently reduced the effect of morphine on this paw but not on the contralateral paw, an effect which plateaued at 30 mu g. By contrast, the local injection of naltrindole (30-40 mu g into the nerve injured paw) had no effect on morphine analgesia. The doses of opioid receptor antagonists used, injected i.v., in the contralateral paw, or alone in the nerve injured paw had no significant effect. These results suggest that the peripheral effect of systemic morphine in this model of neuropathic pain could be mediated not only by mu- but also by kappa-opioid receptors.
引用
收藏
页码:135 / 143
页数:9
相关论文
共 48 条
[1]  
ANTONIJEVIC I, 1995, J NEUROSCI, V15, P165
[2]   ANTINOCICEPTIVE EFFECTS OF ACUTE AND CHRONIC INJECTIONS OF TRICYCLIC ANTIDEPRESSANT DRUGS IN A NEW MODEL OF MONONEUROPATHY IN RATS [J].
ARDID, D ;
GUILBAUD, G .
PAIN, 1992, 49 (02) :279-287
[3]   LACK OF ANALGESIC EFFECT OF OPIOIDS ON NEUROPATHIC AND IDIOPATHIC FORMS OF PAIN [J].
ARNER, S ;
MEYERSON, BA .
PAIN, 1988, 33 (01) :11-23
[4]   BEHAVIORAL EVIDENCE THAT SYSTEMIC MORPHINE MAY MODULATE A PHASIC PAIN-RELATED BEHAVIOR IN A RAT MODEL OF PERIPHERAL MONONEUROPATHY [J].
ATTAL, N ;
CHEN, YL ;
KAYSER, V ;
GUILBAUD, G .
PAIN, 1991, 47 (01) :65-70
[5]   FURTHER EVIDENCE FOR PAIN-RELATED BEHAVIORS IN A MODEL OF UNILATERAL PERIPHERAL MONONEUROPATHY [J].
ATTAL, N ;
JAZAT, F ;
KAYSER, V ;
GUILBAUD, G .
PAIN, 1990, 41 (02) :235-251
[6]   OPIOID AGONISTS AND ANTAGONISTS - AN EVALUATION OF THEIR PERIPHERAL ACTIONS IN INFLAMMATION [J].
BARBER, A ;
GOTTSCHLICH, R .
MEDICINAL RESEARCH REVIEWS, 1992, 12 (05) :525-562
[7]  
BENNETT GJ, 1989, NATO ADV SCI I A-LIF, V176, P463
[8]   A PERIPHERAL MONONEUROPATHY IN RAT THAT PRODUCES DISORDERS OF PAIN SENSATION LIKE THOSE SEEN IN MAN [J].
BENNETT, GJ ;
XIE, YK .
PAIN, 1988, 33 (01) :87-107
[9]   REGULATION OF OPIOID BINDING-SITES IN THE SUPERFICIAL DORSAL HORN OF THE RAT SPINAL-CORD FOLLOWING LOOSE LIGATION OF THE SCIATIC-NERVE - COMPARISON WITH SCIATIC-NERVE SECTION AND LUMBAR DORSAL RHIZOTOMY [J].
BESSE, D ;
LOMBARD, MC ;
PERROT, S ;
BESSON, JM .
NEUROSCIENCE, 1992, 50 (04) :921-933
[10]   HUMAN PERIPHERAL-NERVE MACROPHAGES IN NORMAL AND PATHOLOGICAL CONDITIONS [J].
BONETTI, B ;
MONACO, S ;
GIANNINI, C ;
FERRARI, S ;
ZANUSSO, GL ;
RIZZUTO, N .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 1993, 118 (02) :158-168