Beneficial effect of polymyxin B-immobilized fiber column (PMX) hemoperfusion treatment on acute exacerbation of idiopathic pulmonary fibrosis

被引：62

作者：

Seo, Yoshitsugu

Abe, Shinji ^{[1
]}

Kurahara, Misuzu

Okada, Daisuke ^{[2
]}

Saito, Yoshinobu

Usuki, Jiro

Azuma, Arata

Koizumi, Kiyoshi ^{[3
]}

Kudoh, Shoji

机构：

[1] Nippon Med Sch, Dept Internal Med 4, Bunkyo Ku, Tokyo 1138603, Japan

[2] Aizu Chuo Hosp, Fukushima, Japan

[3] Nippon Med Sch, Dept Surg 2, Tokyo 1138603, Japan

来源：

INTERNAL MEDICINE | 2006年 / 45卷 / 18期

关键词：

acute exacerbation of idiopathic pulmonary fibrosis; polymyxin B-immobilized fiber column (PMX) treatment; alveolar-arterial difference of oxygen (AaDO(2)); KL-6; lactate dehydrogenase (LDH);

D O I：

10.2169/internalmedicine.45.6018

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective This study was aimed to investigate the effect of polymyxin B-immobilized fiber column (PMX) hemoperfusion treatment on the acute exacerbation of idiopathic pulmonary fibrosis (IPF). Patients and Methods Six patients with a clinical diagnosis of idiopathic pulmonary fibrosis (IPF) who developed acute exacerbation were included in this study. Although five of six patients were treated with high-dose corticosteroid therapy, mechanical ventilation was necessary for all six patients due to severe respiratory failure. Blood endotoxin levels were undetectable in all patients. PMX treatment was performed on these six patients. Results In four of six patients, alveolar-arterial difference of oxygen (AaDO(2)), serum KL-6 and lactate dehydrogenase (LDH) were improved after PMX treatment. These four patients were successfully weaned from mechanical ventilation and survived more than 30 days after the initial PMX treatment. Conclusion These data suggest a potential beneficial effect of PMX treatment on acute exacerbation of IPF.

引用

页码：1033 / 1038

页数：6

共 26 条

[11] Early hemoperfusion with an immobilized polymyxin B fiber column eliminates humoral mediators and improves pulmonary oxygenation [J].