Mitochondrial Dynamics in Stem Cells and Differentiation

被引：142
|
作者：
Seo, Bong Jong [1 ]
Yoon, Sang Hoon [1 ]
Do, Jeong Tae [1 ]
机构：
[1] Konkuk Univ, Konkuk Inst Technol, Dept Stem Cell & Regenerat Biotechnol, Seoul 05020, South Korea
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 12期
基金：
新加坡国家研究基金会;
关键词：
mitochondria; mitochondrial dynamics; fusion; fission; pluripotency; differentiation; DEPENDENT PROTEIN-KINASE; ENDOPLASMIC-RETICULUM; OXIDATIVE STRESS; SKELETAL-MUSCLE; FISSION; DRP1; FUSION; OPA1; GTPASE; MITOPHAGY;
D O I：
10.3390/ijms19123893
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mitochondria are highly dynamic organelles that continuously change their shape. Their main function is adenosine triphosphate (ATP) production; however, they are additionally involved in a variety of cellular phenomena, such as apoptosis, cell cycle, proliferation, differentiation, reprogramming, and aging. The change in mitochondrial morphology is closely related to the functionality of mitochondria. Normal mitochondrial dynamics are critical for cellular function, embryonic development, and tissue formation. Thus, defects in proteins involved in mitochondrial dynamics that control mitochondrial fusion and fission can affect cellular differentiation, proliferation, cellular reprogramming, and aging. Here, we review the processes and proteins involved in mitochondrial dynamics and their various associated cellular phenomena.
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页数：20
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