Why is Chromosome Segregation Error in Oocytes Increased With Maternal Aging?

被引：36

作者：

Wang, Zhen-Bo ^{[1
]}

Schatten, Heide ^{[2
]}

Sun, Qing-Yuan ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing, Peoples R China

[2] Univ Missouri, Dept Vet Pathol, Columbia, MO USA

来源：

PHYSIOLOGY | 2011年 / 26卷 / 05期

基金：

中国国家自然科学基金;

关键词：

SPINDLE-ASSEMBLY CHECKPOINT; SISTER-CHROMATID COHESION; SENESCENCE-ACCELERATED MICE; GERM-CELL ANEUPLOIDY; IN-VITRO MATURATION; MOUSE MEIOSIS I; MAMMALIAN OOCYTES; BISPHENOL-A; HISTONE ACETYLATION; GENE-EXPRESSION;

D O I：

10.1152/physiol.00020.2011

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

It is well documented that female fertility is decreased with advanced maternal age due to chromosome abnormality in oocytes. Increased chromosome missegregation is mainly caused by centromeric cohesion reduction. Other factors such as weakened homologous recombination, improper spindle organization, spindle assembly checkpoint (SAC) malfunction, chromatin epigenetic changes, and extra-oocyte factors may also cause chromosome errors.

引用

页码：314 / 325

页数：12