Mechanisms of protein folding

被引：15

作者：

Ivarsson, Ylva ^{[1
]}

Travaglini-Allocatelli, Carlo ^{[1
]}

Brunori, Maurizio ^{[1
]}

Gianni, Stefano ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Ist Biol Patol Mol, Dipartimento Sci Biochim A Rossi Fanelli, I-00185 Rome, Italy

来源：

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS | 2008年 / 37卷 / 06期

关键词：

protein folding; transition state; nucleation-condensation; diffusion-collision; folding kinetics; downhill folding;

D O I：

10.1007/s00249-007-0256-x

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Understanding the mechanism by which a polypeptide chain folds into its native structure is a central problem of modern biophysics. The collaborative efforts of experimental and theoretical studies recently raised the tantalizing possibility to define a unifying mechanism for protein folding. In this review we summarize some of these intriguing advances and analyze them together with a discussion on the new findings concerning the so-called downhill folding.

引用

页码：721 / 728

页数：8

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