Acute liver injury following short-term use of the herbal supplement kratom

被引：4

作者：

Umbehr, Gabriel ^{[1
]}

Lukaszewicz, Magdalena ^{[2
]}

机构：

[1] Quinnipiac PA Program, Hamden, CT 06518 USA

[2] Quinnipiac Univ, PA Program, Hamden, CT 06518 USA

来源：

JAAPA-JOURNAL OF THE AMERICAN ACADEMY OF PHYSICIAN ASSISTANTS | 2022年 / 35卷 / 02期

关键词：

kratom; liver injury; hepatotoxicity; hyperbilirubinemia; herbal supplement; Mitragyna; MITRAGYNA-SPECIOSA; STATES;

D O I：

10.1097/01.JAA.0000805820.94245.3d

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Kratom, a tropical plant and dietary supplement with dose-dependent effects, has physiologic effects similar to opioids as well as stimulant effects. Kratom, like all dietary supplements, is not regulated in the United States and its effects have raised potential and safety concerns. This article describes a patient who presented to the ED with jaundice and acute liver injury, which after a thorough exclusion of alternative causes was attributed to kratom use.

引用

页码：39 / 41

页数：3

共 16 条

[1] Mitragyna speciosa use in the northern states of Malaysia: A cross-sectional study
Ahmad, Kamarudin
Aziz, Zoriah
[J]. JOURNAL OF ETHNOPHARMACOLOGY, 2012, 141 (01) : 446 - 450
[2] Herb-Induced Liver Injury With Cholestasis and Renal Injury Secondary to Short-Term Use of Kratom (Mitragyna speciosa)
Antony, Andrew
Lee, Tai-Ping
[J]. AMERICAN JOURNAL OF THERAPEUTICS, 2019, 26 (04) : E546 - E547
[3] ALKALOIDS FROM MITRAGYNA SPECIOSA (KORTH)
BECKETT, AH
SHELLARD, EJ
PHILLIPS.JD
LEE, CM
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1965, 17 (11) : 753 - &
[4] ACG Clinical Guideline: The Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury
Chalasani, Naga P.
Hayashi, Paul H.
Bonkovsky, Herbert L.
Navarro, Victor J.
Lee, William M.
Fontana, Robert J.
[J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2014, 109 (07) : 950 - 966
[5] Cholestatic Hepatitis From Prolonged Kratom Use: A Case Report
Dorman, Christina
Wong, Mark
Khan, Aazib
[J]. HEPATOLOGY, 2015, 61 (03) : 1086 - 1087
[6] Drug Enforcement Administration (DEA), 2005, MICR B, V38, P114
[7] KRATOM EXPOSURES REPORTED TO TEXAS POISON CENTERS
Forrester, Mathias B.
[J]. JOURNAL OF ADDICTIVE DISEASES, 2013, 32 (04) : 396 - 400
[8] Intrahepatic Cholestasis Following Abuse of Powdered Kratom (Mitragyna speciosa)
Kapp F.G.
Maurer H.H.
Auwärter V.
Winkelmann M.
Hermanns-Clausen M.
[J]. Journal of Medical Toxicology, 2011, 7 (3) : 227 - 231
[9] Unintentional Drug Overdose Deaths with Kratom Detected-27 States, July 2016-December 2017
Olsen, Emily O'Malley
O'Donnell, Julie
Mattson, Christine L.
Schier, Joshua G.
Wilson, Nana
[J]. MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2019, 68 (14): : 326 - 327
[10] Studies on the metabolism of mitragynine, the main alkaloid of the herbal drug Kratom, in rat and human urine using liquid chromatography-linear ion trap mass spectrometry
Philipp, Anika A.
Wissenbach, Dirk K.
Zoerntlein, Siegfried W.
Klein, Oliver N.
Kanogsunthornrat, Jidapha
Maurer, Hans H.
[J]. JOURNAL OF MASS SPECTROMETRY, 2009, 44 (08): : 1249 - 1261

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