Regioselective Synthesis of Fused Oxazepinone Scaffolds through One-Pot Smiles Rearrangement Tandem Reaction

被引：48
作者：
Liu, Yanli [1 ]
Chu, Chunxiao [1 ]
Huang, Aiping [1 ]
Zhan, Chunjing [1 ]
Ma, Ying [1 ]
Ma, Chen [1 ,2 ]
机构：
[1] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China
[2] Peking Univ, Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
来源：
ACS COMBINATORIAL SCIENCE | 2011年 / 13卷 / 05期
基金：
美国国家科学基金会;
关键词：
one-pot; coupling/Smiles rearrangement/cyclization process; fused oxazepinone scaffolds; HIV-1; REVERSE-TRANSCRIPTASE; NONNUCLEOSIDE INHIBITORS;
D O I：
10.1021/co2001058
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The paper describes a convenient and facile methodology for the regioselective synthesis of fused oxazepinone scaffolds. This process is an efficient construction of the oxazepinone scaffold by a one-pot coupling/Smiles rearrangement/cyclization approach. This transition metal-free process has potential applications in the synthesis of biologically and medicinally relevant compounds.
引用
收藏
页码：547 / 553
页数：7
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