Behavioural correlates of striatal glial fibrillary acidic protein in the 3-nitropropionic acid rat model: Disturbed walking pattern and spatial orientation

被引:58
作者
Teunissen, CE [1 ]
Steinbusch, HWM [1 ]
Angevaren, M [1 ]
Appels, M [1 ]
De Bruijn, C [1 ]
Prickaerts, J [1 ]
De Vente, J [1 ]
机构
[1] Univ Maastricht, Dept Psychiat & Neuropsychol, European Grad Sch Neurosci Euron, NL-6200 MD Maastricht, Netherlands
关键词
3-nitropropionic acid; striatal lesions; glial fibrillary acidic protein; spatial learning; rats;
D O I
10.1016/S0306-4522(01)00164-6
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The 3-nitropropionic acid animal model is a model where excitotoxicity, mitochondrial dysfunction and oxidative stress, mechanisms common to various neurodegenerative diseases, are involved. The present study investigated whether behavioural alterations in this model were related to striatal damage. Wistar and Lewis rats were exposed to 3-nitropropionic acid and their behavioural performance (open field, walking pattern and Morris Water Maze task) was tested after the injections and after a recovery period of 3 weeks. No changes in activity were found in the open field test. Altered walking pattern was observed in the footprint analysis, although a different response was observed in the Wistar rats compared to the Lewis rats. Initially increased latency times were observed during visual discrimination learning in the Morris Water Maze task in 3-nitropropionic acid-treated Wistar rats compared to Wistar controls. During spatial discrimination learning (invisible platform) in the Morris Water Maze task the swimming velocity was decreased in both rat strains as a result of 3-nitropropionic acid treatment. Increased striatal glial fibrillary acidic protein concentration in Wistar rats correlated with several parameters of the footprint analysis and with-the latency and distance in visual as well as spatial discrimination learning in the Morris Water Maze. It is concluded that measurement of walking pattern and spatial orientation performance are sensitive indicators to monitor behavioural changes in relation to striatal degeneration in the 3-nitropropionic acid animal model. In addition, Lewis rats are less sensitive towards 3-nitropropionic acid treatment than Wistar rats. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:153 / 167
页数:15
相关论文
共 48 条
[11]   SOMATOTOPIC ORGANIZATION IN RAT STRIATUM - EVIDENCE FOR A COMBINATIONAL MAP [J].
BROWN, LL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (16) :7403-7407
[12]   AN INDEX OF THE FUNCTIONAL-CONDITION OF RAT SCIATIC-NERVE BASED ON MEASUREMENTS MADE FROM WALKING TRACKS [J].
DEMEDINACELI, L ;
FREED, WJ ;
WYATT, RJ .
EXPERIMENTAL NEUROLOGY, 1982, 77 (03) :634-643
[13]   Dissociation of hippocampal and striatal contributions to spatial navigation in the water maze [J].
Devan, BD ;
Goad, EH ;
Petri, HL .
NEUROBIOLOGY OF LEARNING AND MEMORY, 1996, 66 (03) :305-323
[14]  
Duckworth EA, 1999, PSYCHOBIOLOGY, V27, P561
[15]   MOLECULAR PROFILE OF REACTIVE ASTROCYTES - IMPLICATIONS FOR THEIR ROLE IN NEUROLOGIC DISEASE [J].
EDDLESTON, M ;
MUCKE, L .
NEUROSCIENCE, 1993, 54 (01) :15-36
[16]   Astrocytes are more vulnerable than neurons to cellular Ca2+ overload induced by a mitochondrial toxin, 3-nitropropionic acid [J].
Fukuda, A ;
Deshpande, SB ;
Shimano, Y ;
Nishino, H .
NEUROSCIENCE, 1998, 87 (02) :497-507
[17]   Quantifiable bradykinesia, gait abnormalities and Huntington's disease-like striatal lesions in rats chronically treated with 3-nitropropionic acid [J].
Guyot, MC ;
Hantraye, P ;
Dolan, R ;
Palfi, SM ;
Maziere, M ;
Brouillet, E .
NEUROSCIENCE, 1997, 79 (01) :45-56
[18]  
HAMILTON V, 1987, PSYCHOANAL PSYCHOL, V3, P67
[19]  
HASSEL B, 1995, J NEUROCHEM, V65, P1184
[20]   Nitric oxide, mitochondria and neurological disease [J].
Heales, SJR ;
Bolaños, JP ;
Stewart, VC ;
Brookes, PS ;
Land, JM ;
Clark, JB .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1999, 1410 (02) :215-228