Expression of hTERT in placenta of IUGR pregnancy in an Iranian population

被引:0
作者
Rafiee, Sara [1 ]
Tamandani, Dor Mohammad Kordi [1 ]
Rigi, Mehrnaz Saroone [2 ]
Ghanbari, Mohammad Ali [3 ]
Pouresmaeili, Farkhondeh [4 ]
机构
[1] Univ Sistan & Baluchestan, Dept Biol, Zahedan, Iran
[2] Shafa Surg Ctr, Zahedan, Iran
[3] Shahid Beheshti Univ Med Sci, IRHRC, Tehran, Iran
[4] Shahid Beheshti Univ Med Sci, Med Genet Dept, Fac Med, Tehran, Iran
关键词
IUGR; Placenta; Pregnancy; hTERT; INTRAUTERINE GROWTH RESTRICTION; LOW-BIRTH-WEIGHT; PREVALENCE; MORTALITY;
D O I
10.1016/j.mgene.2018.12.005
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Objective: Intrauterine growth restriction (IUGR) is one of the most important causes of the fetus and newborn mortality in the population. The aim of this study was to investigate the relationship between hTERT gene expression level and IUGR pregnancy in an Iranian population. Study design: The hTERT expression was analyzed in 66 placenta samples consisting of 33 controls and 33 IUGRs, and compared by Real-Time Polymerase Chain Reaction (PCR). The results were statistically analyzed using SPSS software. Results: There was no significant difference between the placentas samples of IUGR and healthy individuals for hTERT gene expression (p = 0.621). Conclusions: To the best of our knowledge, the current investigation is the first study on the association between hTERT gene expression and IUGR in Iran. According to our results, there was no significant correlation between hTERT and IUGR etiology in this study. Surely, using more samples could provide more definite results on this matter in the future.
引用
收藏
页码:199 / 202
页数:4
相关论文
共 50 条
  • [21] Expression and potential role of peroxisome proliferator-activated receptor γ in the placenta of diabetic pregnancy
    Suwaki, N.
    Masuyama, H.
    Masumoto, A.
    Takamoto, N.
    Hiramatsu, Y.
    PLACENTA, 2007, 28 (04) : 315 - 323
  • [22] Maternal blood mitochondrial DNA content during normal and intrauterine growth restricted (IUGR) pregnancy
    Colleoni, Francesca
    Lattuada, Debora
    Garretto, Ambra
    Massari, Maddalena
    Mando, Chiara
    Somigliana, Edgardo
    Cetin, Irene
    AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2010, 203 (04) : 365.e1 - 365.e6
  • [23] Altered expression of the imprinted transcription factor PLAGL1 deregulates a network of genes in the human IUGR placenta
    Iglesias-Platas, Isabel
    Martin-Trujillo, Alex
    Petazzi, Paolo
    Guillaumet-Adkins, Amy
    Esteller, Manel
    Monk, David
    HUMAN MOLECULAR GENETICS, 2014, 23 (23) : 6275 - 6285
  • [24] A case of placenta accreta complicated by severe IUGR and maternal coagulopathy
    Okada, Mayumi
    Mitsui, Takashi
    Morita, Takafumi
    Nomura, Mami
    Ohta, Toyohiro
    Itakura, Atsuo
    ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 2007, 86 (06) : 760 - 762
  • [25] Vitamin D effects on pregnancy and the placenta
    Shin, J. S.
    Choi, M. Y.
    Longtine, M. S.
    Nelson, D. M.
    PLACENTA, 2010, 31 (12) : 1027 - 1034
  • [26] Diagnosis and Management of IUGR in Pregnancy Complicated by Type 1 Diabetes Mellitus
    Gutaj, Pawel
    Wender-Ozegowska, Ewa
    CURRENT DIABETES REPORTS, 2016, 16 (05)
  • [27] Diagnosis and Management of IUGR in Pregnancy Complicated by Type 1 Diabetes Mellitus
    Paweł Gutaj
    Ewa Wender-Ozegowska
    Current Diabetes Reports, 2016, 16
  • [28] Chronic Hypertension in Pregnancy and Placenta-Mediated Complications Regardless of Preeclampsia
    Cohen, Yair
    Gutvirtz, Gil
    Avnon, Taeer
    Sheiner, Eyal
    JOURNAL OF CLINICAL MEDICINE, 2024, 13 (04)
  • [29] Expression and distribution of Notch protein members in human placenta throughout pregnancy
    De Falco, M.
    Cobellis, L.
    Giraldi, D.
    Mastrogiacomo, A.
    Perna, A.
    Colacurci, N.
    Miele, L.
    De Luca, A.
    PLACENTA, 2007, 28 (2-3) : 118 - 126
  • [30] Vascular endothelial growth factor expression in placenta of hypertensive disorder in pregnancy
    Azliana, Abd Fuaat
    Zainul-Rashid, Mohamad Razi
    Chandramaya, Sabrina Florence
    Farouk, Wirda Indah
    Nurwardah, Alfian
    Wong, Yin Ping
    Tan, Geok Chin
    INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY, 2017, 60 (04) : 515 - 520