Cannabinoid receptor 1 (CNR1) gene variant moderates neural index of cognitive disruption during nicotine withdrawal

被引:12
作者
Evans, D. E. [1 ,2 ,3 ]
Sutton, S. K. [1 ,2 ,3 ,4 ]
Jentink, K. G. [5 ]
Lin, H. -Y. [6 ]
Park, J. Y. [1 ,2 ,3 ]
Drobes, D. J. [1 ,2 ,3 ]
机构
[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Hlth Outcomes & Behav, Tampa, FL USA
[2] Univ S Florida, Dept Oncol Sci, Tampa, FL USA
[3] Univ S Florida, Dept Psychol, Tampa, FL USA
[4] H Lee Moffitt Canc Ctr & Res Inst, Dept Biostat & Bioinformat, Tampa, FL USA
[5] Colorado State Univ, Dept Psychol, Ft Collins, CO 80523 USA
[6] Louisiana State Univ, Dept Biostat, Baton Rouge, LA 70803 USA
关键词
Alpha-1; cannabinoid; CNR1; cognitive control; EEG; ERP; genetics; nicotine withdrawal; smoking; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DORSOLATERAL PREFRONTAL CORTEX; EEG; ANTAGONIST; DEPENDENCE; POLYMORPHISMS; ASSOCIATION; DEPRIVATION; CHILDREN; SMOKERS;
D O I
10.1111/gbb.12311
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Nicotine withdrawal-related disruption of cognitive control may contribute to the reinforcement of tobacco use. Identification of gene variants that predict this withdrawal phenotype may lead to tailored pharmacotherapy for smoking cessation. Variation on the cannabinoid receptor 1 gene (CNR1) has been related to nicotine dependence, and CNR1 antagonists may increase attention and memory functioning. We targeted CNR1 variants as moderators of a validated neural marker of nicotine withdrawal-related cognitive disruption. CNR1 polymorphisms comprising the TAG' haplotype (rs806379, rs1535255 and rs2023239) were tested independently, as no participants in this sample possessed this haplotype. Nicotine withdrawal-related cognitive disruption was indexed as increased resting electroencephalogram (EEG) alpha-1 power density across 17 electrodes. Seventy-three Caucasian Non-Hispanic smokers (15 cigarettes per day) visited the laboratory on two occasions following overnight smoking/nicotine deprivation. Either two nicotine or two placebo cigarettes were smoked prior to collecting EEG data at each session. Analyses showed that rs806379 moderated the effects of nicotine deprivation increasing slow wave EEG (P = 0.004). Smokers homozygous for the major allele exhibited greater nicotine withdrawal-related cognitive disruption. The current findings suggest potential efficacy of cannabinoid receptor antagonism as a pharmacotherapy approach for smoking cessation among individuals who exhibit greater nicotine withdrawal-related cognitive disruption.
引用
收藏
页码:621 / 626
页数:6
相关论文
共 30 条
[1]   Cognitive function during nicotine withdrawal: Implications for nicotine dependence treatment [J].
Ashare, Rebecca L. ;
Falcone, Mary ;
Lerman, Caryn .
NEUROPHARMACOLOGY, 2014, 76 :581-591
[2]   Effects of stimulant medications on the EEG of children with attention-deficit/hyperactivity disorder [J].
Clarke, AR ;
Barry, RJ ;
Bond, D ;
McCarthy, R ;
Selikowitz, M .
PSYCHOPHARMACOLOGY, 2002, 164 (03) :277-284
[3]   SR141716, a central cannabinoid (CB1) receptor antagonist, blocks the motivational and dopamine-releasing effects of nicotine in rats [J].
Cohen, C ;
Perrault, G ;
Voltz, C ;
Steinberg, R ;
Soubrié, P .
BEHAVIOURAL PHARMACOLOGY, 2002, 13 (5-6) :451-463
[4]   CB1 receptor antagonism increases hippocampal acetylcholine release:: Site and mechanism of action [J].
Degroot, Aldemar ;
Kofalvi, Attila ;
Wade, Mark R. ;
Davis, Richard J. ;
Rodrigues, Ricardo J. ;
Rebola, Nelson ;
Cunha, Rodrigo A. ;
Nomikos, George G. .
MOLECULAR PHARMACOLOGY, 2006, 70 (04) :1236-1245
[5]   Development of Cannabinoid 1 Receptor Protein and Messenger RNA in Monkey Dorsolateral Prefrontal Cortex [J].
Eggan, Stephen M. ;
Mizoguchi, Yoshito ;
Stoyak, Samuel R. ;
Lewis, David A. .
CEREBRAL CORTEX, 2010, 20 (05) :1164-1174
[6]   Cortical activity differs during nicotine deprivation versus satiation in heavy smokers [J].
Evans, David E. ;
Sutton, Steven K. ;
Oliver, Jason A. ;
Drobes, David J. .
PSYCHOPHARMACOLOGY, 2015, 232 (11) :1879-1885
[7]   7 mg nicotine patch fails to enhance P300 neural indices of cognitive control among nonsmokers [J].
Evans, David E. ;
Jentink, Kade G. ;
Sutton, Steven K. ;
Van Rensburg, Kate Janse ;
Drobes, David J. .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2014, 126 :77-82
[8]   Nicotine Deprivation Influences P300 Markers of Cognitive Control [J].
Evans, David E. ;
Maxfield, Nathan D. ;
Van Rensburg, Kate Janse ;
Oliver, Jason A. ;
Jentink, Kade G. ;
Drobes, David J. .
NEUROPSYCHOPHARMACOLOGY, 2013, 38 (12) :2525-2531
[9]   Nicotine self-medication of cognitive-attentional processing [J].
Evans, David E. ;
Drobes, David J. .
ADDICTION BIOLOGY, 2009, 14 (01) :32-42
[10]  
Fernandez Jose R, 2004, Curr Opin Investig Drugs, V5, P430