Synthesis, Experimental and Theoretical Study on the Structure of Some Semicarbazides with Potential Antibacterial Activity

被引：9

作者：

Pitucha, Monika ^{[1
]}

Karczmarzyk, Zbigniew ^{[2
]}

Kosikowska, Urszula ^{[3
]}

Malm, Anna ^{[3
]}

机构：

[1] Med Univ, Dept Organ Chem, PL-20093 Lublin, Poland

[2] Univ Podlasie, Dept Chem, PL-08110 Siedlce, Poland

[3] Med Univ, Dept Pharmaceut Microbiol, PL-20093 Lublin, Poland

来源：

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES | 2011年 / 66卷 / 05期

关键词：

Semicarbazides; Keto-Enol Tautomerism; Gas Phase; Antibacterial Activity; RHF/SCF/6-31G** Calculations; DERIVATIVES; ANTICONVULSANT;

D O I：

10.5560/ZNB.2011.66b0505

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of 1,4-disubstituted semicarbazide and 4,4'-bis[1-substituted semicarbazide]diphenylmethane derivatives were synthesized to explore their antibacterial activity. New compounds were characterized by elemental analysis and spectroscopic data. In order to find the tautomeric equilibrium for the molecules energy calculations for each possible tautomeric form of model compound 2, and for the most antibacterially active compound 7 in the investigated series, were calculated for the gas phase at the RHF/SCF/6-31G** level of theory.

引用

页码：505 / 511

页数：7

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