Dissecting the Neural Circuitry for Pain Modulation and Chronic Pain: Insights from Optogenetics

被引：22

作者：

Guo, Fang ^{[1
,2
]}

Du, Yu ^{[1
,2
]}

Qu, Feng-Hui ^{[1
,2
]}

Lin, Shi-Da ^{[1
,2
]}

Chen, Zhong ^{[3
]}

Zhang, Shi-Hong ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Dept Pharmacol, Sch Med, Affiliated Hosp 2, Hangzhou 310058, Peoples R China

[2] Zhejiang Univ, Dept Anesthesiol, Sch Med, Affiliated Hosp 2, Hangzhou 310058, Peoples R China

[3] Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Key Lab Neuropharmacol & Translat Med Zhejiang Pr, Hangzhou 310053, Peoples R China

来源：

NEUROSCIENCE BULLETIN | 2022年 / 38卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Optogenetics; Pain transmission; Pain modulation; Chronic pain; Neural circuits; ANTERIOR CINGULATE CORTEX; MIDCINGULATE CORTEX; CENTRAL AMYGDALA; NUCLEUS; NEURONS; HYPERSENSITIVITY; STIMULATION; NOCICEPTION; ACTIVATION; IDENTIFICATION;

D O I：

10.1007/s12264-022-00835-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Pain is an unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage. The processing of pain involves complicated modulation at the levels of the periphery, spinal cord, and brain. The pathogenesis of chronic pain is still not fully understood, which makes the clinical treatment challenging. Optogenetics, which combines optical and genetic technologies, can precisely intervene in the activity of specific groups of neurons and elements of the related circuits. Taking advantage of optogenetics, researchers have achieved a body of new findings that shed light on the cellular and circuit mechanisms of pain transmission, pain modulation, and chronic pain both in the periphery and the central nervous system. In this review, we summarize recent findings in pain research using optogenetic approaches and discuss their significance in understanding the pathogenesis of chronic pain.

引用

页码：440 / 452

页数：13

共 100 条

[1] The cell and molecular basis of mechanical, cold, and inflammatory pain [J].