Are we ready for industrial production of bioactive plant secondary metabolites utilizing endophytes?

被引：132
作者：
Kusari, Souvik [1 ]
Spiteller, Michael [1 ]
机构：
[1] TU Dortmund, Chair Environm Chem & Analyt Chem, Fac Chem, Inst Environm Res INFU, D-44221 Dortmund, Germany
来源：
NATURAL PRODUCT REPORTS | 2011年 / 28卷 / 07期
关键词：
HORIZONTAL GENE-TRANSFER; HYPERICUM-PERFORATUM; NATURAL-PRODUCTS; DRUG DISCOVERY; FUNGUS; PODOPHYLLOTOXIN; MICROORGANISMS; BIOSYNTHESIS; BIODIVERSITY; DIVERSITY;
D O I：
10.1039/c1np00030f
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The prospect of endophytes capable of producing associated plant natural products with therapeutic potential is undeniable. However, the unyielding struggle so far to transform these potential sources into sustainable microbial manufacturers on a commercial scale has been disappointing. In this Viewpoint, we address this trade-off between endophyte discovery and viable industrial application.
引用
收藏
页码：1203 / 1207
页数：5
相关论文
共 43 条
  • [1] Arnold A.E., 2008, TROPICAL FOREST COMM, P254
  • [2] Fungal endophytes limit pathogen damage in a tropical tree
    Arnold, AE
    Mejía, LC
    Kyllo, D
    Rojas, EI
    Maynard, Z
    Robbins, N
    Herre, EA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (26) : 15649 - 15654
  • [3] Horizontal gene transfer in evolution: facts and challenges
    Boto, Luis
    [J]. PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2010, 277 (1683) : 819 - 827
  • [4] Carroll G.C., 1991, Microbial ecology of leaves, P358, DOI [10.1007/978-1-4612-3168-4_18, DOI 10.1007/978-1-4612-3168-4_18]
  • [5] Genome mining for novel natural product discovery
    Challis, Gregory L.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (09) : 2618 - 2628
  • [6] Metabolic engineering for plant natural product biosynthesis in microbes
    Chemler, Joseph A.
    Koffas, Mattheos A. G.
    [J]. CURRENT OPINION IN BIOTECHNOLOGY, 2008, 19 (06) : 597 - 605
  • [7] Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms
    Chiang, Yi-Ming
    Chang, Shu-Lin
    Oakley, Berl R.
    Wang, Clay C. C.
    [J]. CURRENT OPINION IN CHEMICAL BIOLOGY, 2011, 15 (01) : 137 - 143
  • [8] Lessons from natural molecules
    Clardy, J
    Walsh, C
    [J]. NATURE, 2004, 432 (7019) : 829 - 837
  • [9] Natural resources: Bioprospects less than golden
    Dalton, R
    [J]. NATURE, 2004, 429 (6992) : 598 - 600
  • [10] Endophyte fungal isolates from Podophyllum peltatum produce podophyllotoxin
    Eyberger, Amy L.
    Dondapati, Rajeswari
    Porter, John R.
    [J]. JOURNAL OF NATURAL PRODUCTS, 2006, 69 (08): : 1121 - 1124
12345