Anti-allergic prenylated flavonoids from the roots of Sophora flavescens

被引：21

作者：

Quan, Wenying ^{[1
]}

Lee, Hee Ju ^{[2
]}

Kim, Chul Young ^{[2
]}

Noh, Chu Won

Um, Byung Hun ^{[2
]}

Oak, Min-Ho ^{[1
]}

Kim, Kyeong-Man ^{[1
]}

机构：

[1] Chonnam Natl Univ, Dept Pharmacol, Coll Pharm, Drug Dev Res Ctr, Kwangju 500757, South Korea

[2] KIST Gangneung Inst, Nat Prod Res Ctr, Kangnung, Gangwon Do, South Korea

来源：

PLANTA MEDICA | 2008年 / 74卷 / 02期

关键词：

Sophora flavescens; Leguminosae; anti-allergic activity; prenylated flavonoids;

D O I：

10.1055/s-2008-1034285

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The bioassay-guided fractionation of the MeOH extract from the root of Sophora flavescens led to the isolation of eight known prenylated flavonoids (11 -8) responsible for the in vitro anti-allergic activity. Among them, kushenol N (3), sophoraflavanone G (6), and leachianone A (7) demonstrated significant inhibition of the release of beta-hexosaminidase from cultured RBL-2H3 cells with IC50 values ranging from 15 to 30 mu M.

引用

页码：168 / 170

页数：3

共 50 条

[31] Phytochemistry and biological properties of isoprenoid flavonoids from Sophora flavescens Ait
Li, Jing-jing
Zhang, Xu
Shen, Xiang-chun
Long, Qing-de
Xu, Chang-yan
Tan, Chuan-jiao
Lin, Yan
FITOTERAPIA, 2020, 143
[32] Prenylated flavonoids from Sophora flavescens inhibit mushroom tyrosinase activity and modulate melanogenesis in murine melanoma cells and zebrafish
Fan, Fenling
Chen, Lanqing
Chen, Caihong
Ang, Song
Gutkowski, Justin
Seeram, Navindra P.
Ma, Hang
Li, Dongli
FRONTIERS IN PHARMACOLOGY, 2024, 15
[33] Five New Alkaloids from the Roots of Sophora flavescens
Zhang, Sheng-Yuan
Li, Wen
Nie, Hua
Liao, Mei
Qiu, Bo
Yang, Ya-Li
Chen, Yan-Fen
CHEMISTRY & BIODIVERSITY, 2018, 15 (03)
[34] A Novel Pterocarpan Derivative From the Roots of Sophora flavescens
Zhang, Zhi-Jun
Li, Guo-Xian
Liu, Dan
Chen, Xuan-Qin
Li, Hong-Mei
Li, Rong-Tao
NATURAL PRODUCT COMMUNICATIONS, 2020, 15 (10)
[35] Anti-Inflammatory and Antiproliferative Activities of Trifolirhizin, a Flavonoid from Sophora flavescens Roots
Zhou, Huiping
Lutterodt, Herman
Cheng, Zhihong
Yu, Liangli
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2009, 57 (11) : 4580 - 4585
[36] Human ACAT Inhibitory Effects of Flavonoids from Sophora flavescens
Jeong, Tae-Sook
An, Sojin
Ryu, Young Bae
Kim, Hoi Young
Cho, Moon-Hee
Park, Ji-Sun
Park, Ki Hun
Lee, Woo Song
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2008, 29 (11): : 2287 - 2290
[37] Two New Isoprenoid Flavonoids from Sophora flavescens with Antioxidant and Cytotoxic Activities
Li, Jingjing
Lin, Yan
He, Lei
Ou, Rongxiu
Chen, Tao
Zhang, Xu
Li, Qirui
Zeng, Zhu
Long, Qingde
MOLECULES, 2021, 26 (23):
[38] Fast identification of flavonoids in the roots of Sophora flavescens by on-flow LC-NMR
Kim, Su Jin
Kim, Sang Min
Kim, Min Cheol
Kang, Suk Woo
Um, Byung Hun
JOURNAL OF MEDICINAL PLANTS RESEARCH, 2010, 4 (23): : 2452 - 2459
[39] Prenylated Dihydroflavonol from Sophora flavescens Regulate the Polarization and Phagocytosis of Macrophages In Vitro
Su, Lu
Rao, Kairui
Wang, Lizhong
Pu, Li
Zhang, Zhijun
Li, Hongmei
Li, Rongtao
Liu, Dan
MOLECULES, 2024, 29 (19):
[40] Potential anti-allergic acridone alkaloids from the roots of Atalantia monophylla
Chukaew, Arnon
Ponglimanont, Chanita
Karalai, Chatchanok
Tewtrakul, Supinyal
PHYTOCHEMISTRY, 2008, 69 (14) : 2616 - 2620

← 1 2 3 4 5 →