Anti-allergic prenylated flavonoids from the roots of Sophora flavescens

被引：21

作者：

Quan, Wenying ^{[1
]}

Lee, Hee Ju ^{[2
]}

Kim, Chul Young ^{[2
]}

Noh, Chu Won

Um, Byung Hun ^{[2
]}

Oak, Min-Ho ^{[1
]}

Kim, Kyeong-Man ^{[1
]}

机构：

[1] Chonnam Natl Univ, Dept Pharmacol, Coll Pharm, Drug Dev Res Ctr, Kwangju 500757, South Korea

[2] KIST Gangneung Inst, Nat Prod Res Ctr, Kangnung, Gangwon Do, South Korea

来源：

PLANTA MEDICA | 2008年 / 74卷 / 02期

关键词：

Sophora flavescens; Leguminosae; anti-allergic activity; prenylated flavonoids;

D O I：

10.1055/s-2008-1034285

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The bioassay-guided fractionation of the MeOH extract from the root of Sophora flavescens led to the isolation of eight known prenylated flavonoids (11 -8) responsible for the in vitro anti-allergic activity. Among them, kushenol N (3), sophoraflavanone G (6), and leachianone A (7) demonstrated significant inhibition of the release of beta-hexosaminidase from cultured RBL-2H3 cells with IC50 values ranging from 15 to 30 mu M.

引用

页码：168 / 170

页数：3

共 50 条

[21] α-Glucosidase Inhibitors from the Roots of Sophora flavescens
Tran Hong Quang
Nguyen Thi Thanh Ngan
Chau Van Minh
Phan Van Kiem
Bui Huu Tai
Nguyen Phuong Thao
Kwon, Se-Uk
Lee, Young-Mi
Kang, Hee-Kyoung
Kim, Young Ho
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2012, 33 (05) : 1791 - 1793
[22] Low Density Lipoprotein (LDL)-Antioxidant Flavonoids from Roots of Sophora flavescens
Jeong, Tae-Sook
Ryu, Young Bae
Kim, Hoi Young
Curtis-Long, Marcus John
An, So Jin
Lee, Jin Hwan
Lee, Woo Song
Park, Ki Hun
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2008, 31 (11) : 2097 - 2102
[23] Glycosidase inhibitory flavonoids from Sophora flavescens
Kim, JH
Ryu, YB
Kang, NS
Lee, BW
Heo, JS
Jeong, IY
Park, KH
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2006, 29 (02) : 302 - 305
[24] Prenylated flavonoids and derivatives isolated from the root barks of Sophora flavescens as potent antibacterial agents against Staphylococcus aureus
Long, Guo-Qing
Li, Xin-Min
Wang, Dong-Dong
Bao, Te-Ri-Gen
Yang, Yong-Cheng
Zheng, Ying-Ying
Liu, Xuan-Li
Sun, Xian-Duo
Wang, An-Hua
Jia, Jing-Ming
INDUSTRIAL CROPS AND PRODUCTS, 2022, 189
[25] Six undescribed lavandulylated flavonoids with PTP1B inhibition from the roots of Sophora flavescens
Zhang, Xu
Lu, Kai-Zhou
Yang, Ya-Nan
Feng, Zi-Ming
Yuan, Xiang
Jiang, Jian-Shuang
Zhang, Pei-Cheng
PHYTOCHEMISTRY, 2023, 216
[26] Alkaloids from the roots of Sophora flavescens and their anti-tumor activity
Xu, Yang
Wang, Xiuli
Sa, Kuiru
Li, Hua
Chen, Lixia
FITOTERAPIA, 2023, 171
[27] In Vitro Sortase A Inhibitory and Antimicrobial Activity of Flavonoids Isolated from the Roots of Sophora flavescens
Oh, Ikhoon
Yang, Woo-Young
Chung, Soon-Chun
Kim, Tae-Yoon
Oh, Ki-Bong
Shin, Jongheon
ARCHIVES OF PHARMACAL RESEARCH, 2011, 34 (02) : 217 - 222
[28] Protein Tyrosine Phosphatase 1B Inhibitory Activity of Lavandulyl Flavonoids from Roots of Sophora flavescens
Sasaki, Tatsunori
Li, Wei
Higai, Koji
Tran Hong Quang
Kim, Young Ho
Koike, Kazuo
PLANTA MEDICA, 2014, 80 (07) : 557 - 560
[29] In vitro antitumour activity of flavonoids from Sophora flavescens
Ryu, SY
Choi, SU
Kim, SK
No, ZS
Lee, CO
Ahn, JW
Kim, SH
PHYTOTHERAPY RESEARCH, 1997, 11 (01) : 51 - 53
[30] Monoamine oxidase inhibitory components from the roots of Sophora flavescens
Hwang, JS
Lee, SA
Hong, SS
Lee, KS
Lee, MK
Hwang, BY
Ro, JS
ARCHIVES OF PHARMACAL RESEARCH, 2005, 28 (02) : 190 - 194

← 1 2 3 4 5 →