Anti-allergic prenylated flavonoids from the roots of Sophora flavescens

被引：21

作者：

Quan, Wenying ^{[1
]}

Lee, Hee Ju ^{[2
]}

Kim, Chul Young ^{[2
]}

Noh, Chu Won

Um, Byung Hun ^{[2
]}

Oak, Min-Ho ^{[1
]}

Kim, Kyeong-Man ^{[1
]}

机构：

[1] Chonnam Natl Univ, Dept Pharmacol, Coll Pharm, Drug Dev Res Ctr, Kwangju 500757, South Korea

[2] KIST Gangneung Inst, Nat Prod Res Ctr, Kangnung, Gangwon Do, South Korea

来源：

PLANTA MEDICA | 2008年 / 74卷 / 02期

关键词：

Sophora flavescens; Leguminosae; anti-allergic activity; prenylated flavonoids;

D O I：

10.1055/s-2008-1034285

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The bioassay-guided fractionation of the MeOH extract from the root of Sophora flavescens led to the isolation of eight known prenylated flavonoids (11 -8) responsible for the in vitro anti-allergic activity. Among them, kushenol N (3), sophoraflavanone G (6), and leachianone A (7) demonstrated significant inhibition of the release of beta-hexosaminidase from cultured RBL-2H3 cells with IC50 values ranging from 15 to 30 mu M.

引用

页码：168 / 170

页数：3

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