Increased weight gain by C-section: Functional significance of the primordial microbiome

被引：78

作者：

Martinez, Keith A., II ^{[1
,2
]}

Devlin, Joseph C. ^{[1
]}

Lacher, Corey R. ^{[1
]}

Yin, Yue ^{[1
]}

Cai, Yi ^{[1
]}

Wang, Jincheng ^{[1
]}

Dominguez-Bello, Maria G. ^{[1
,2
]}

机构：

[1] NYU, Sch Med, Dept Med, Div Translat Med, New York, NY 10016 USA

[2] NYU, Sch Med, Dept Microbiol, Sackler Inst Grad Biomed Sci, New York, NY 10016 USA

来源：

SCIENCE ADVANCES | 2017年 / 3卷 / 10期

关键词：

DELIVERY; ASSOCIATION; OBESITY; BIRTH; RISK; ADIPOSITY;

D O I：

10.1126/sciadv.aao1874

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Epidemiological evidence supports a direct association between early microbiota impact-including C-section-and obesity. We performed antibiotic-free, fostered C-sections and determined the impact on the early microbiota and body weight during development. Mice in the C-section group gained more body mass after weaning, with a stronger phenotype in females. C-section-born mice lacked the dynamic developmental gut microbiota changes observed in control mice. The results demonstrate a causal relationship between C-section and increased body weight, supporting the involvement of maternal vaginal bacteria in normal metabolic development.

引用

页数：4

共 24 条

[21] Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice [J].

Ridaura, Vanessa K. ;

Faith, Jeremiah J. ;

Rey, Federico E. ;

Cheng, Jiye ;

Duncan, Alexis E. ;

Kau, Andrew L. ;

Griffin, Nicholas W. ;

Lombard, Vincent ;

Henrissat, Bernard ;

Bain, James R. ;

Muehlbauer, Michael J. ;

Ilkayeva, Olga ;

Semenkovich, Clay F. ;

Funai, Katsuhiko ;

Hayashi, David K. ;

Lyle, Barbara J. ;

Martini, Margaret C. ;

Ursell, Luke K. ;

Clemente, Jose C. ;

Van Treuren, William ;

Walters, William A. ;

Knight, Rob ;

Newgard, Christopher B. ;

Heath, Andrew C. ;

Gordon, Jeffrey I. .

SCIENCE, 2013, 341 (6150) :1079-U49

[22] Reagent and laboratory contamination can critically impact sequence-based microbiome analyses [J].

Salter, Susannah J. ;

Cox, Michael J. ;

Turek, Elena M. ;

Calus, Szymon T. ;

Cookson, William O. ;

Moffatt, Miriam F. ;

Turner, Paul ;

Parkhill, Julian ;

Loman, Nicholas J. ;

Walker, Alan W. .

BMC BIOLOGY, 2014, 12

[23] Metagenomic biomarker discovery and explanation [J].

Segata, Nicola ;

Izard, Jacques ;

Waldron, Levi ;

Gevers, Dirk ;

Miropolsky, Larisa ;

Garrett, Wendy S. ;

Huttenhower, Curtis .

GENOME BIOLOGY, 2011, 12 (06)

[24] Association between rates of caesarean section and maternal and neonatal mortality in the 21st century: a worldwide population-based ecological study with longitudinal data [J].

Ye, J. ;

Zhang, J. ;

Mikolajczyk, R. ;

Torloni, M. R. ;

Guelmezoglu, A. M. ;

Betran, A. P. .

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2016, 123 (05) :745-753

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