Increased weight gain by C-section: Functional significance of the primordial microbiome

被引：78

作者：

Martinez, Keith A., II ^{[1
,2
]}

Devlin, Joseph C. ^{[1
]}

Lacher, Corey R. ^{[1
]}

Yin, Yue ^{[1
]}

Cai, Yi ^{[1
]}

Wang, Jincheng ^{[1
]}

Dominguez-Bello, Maria G. ^{[1
,2
]}

机构：

[1] NYU, Sch Med, Dept Med, Div Translat Med, New York, NY 10016 USA

[2] NYU, Sch Med, Dept Microbiol, Sackler Inst Grad Biomed Sci, New York, NY 10016 USA

来源：

SCIENCE ADVANCES | 2017年 / 3卷 / 10期

关键词：

DELIVERY; ASSOCIATION; OBESITY; BIRTH; RISK; ADIPOSITY;

D O I：

10.1126/sciadv.aao1874

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Epidemiological evidence supports a direct association between early microbiota impact-including C-section-and obesity. We performed antibiotic-free, fostered C-sections and determined the impact on the early microbiota and body weight during development. Mice in the C-section group gained more body mass after weaning, with a stronger phenotype in females. C-section-born mice lacked the dynamic developmental gut microbiota changes observed in control mice. The results demonstrate a causal relationship between C-section and increased body weight, supporting the involvement of maternal vaginal bacteria in normal metabolic development.

引用

页数：4

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