Dihalooxygenation of Alkynes and Alkynols: Preparation of 2,2-Dihaloketones and gem-Dihalolactols

被引：6

作者：

Chaisan, Nattawadee ^{[1
]}

Ruengsangtongkul, Sureeporn ^{[2
]}

Thongsornkleeb, Charnsak ^{[1
,2
]}

Tummatorn, Jumreang ^{[1
,2
]}

Ruchirawat, Somsak ^{[1
,2
]}

机构：

[1] Chulabhorn Grad Inst, MHESI, Program Chem Biol, Ctr Excellence Environm Hlth & Toxicol EHT,OPS, 54 Kamphaeng Phet 6, Bangkok 10210, Thailand

[2] Chulabhorn Res Inst, Lab Med Chem, 54 Kamphaeng Phet 6, Bangkok 10210, Thailand

来源：

SYNLETT | 2022年 / 33卷 / 14期

关键词：

dihaloketones; dihalolactols; alkynes; alkynols; halogenation; N-HALOSUCCINIMIDES; HALOGENATION; CATALYST; KETONES;

D O I：

10.1055/a-1774-7077

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild and convenient method for the synthesis of 2,2-dihaloketones and gem-dihalolactols has been developed. For the synthesis of 2,2-dihaloketones, alkynes were employed as substrates to react with halogenating agents, Cl-2 or CIBr, that were generated in situ from aqueous HCl and NCS or NBS, respectively. On the other hand, gem-dihalolactols could be prepared from alkynol substrates by using the same reaction conditions. This method could be applied to a broad range of substrates to give the corresponding products in low to good yields.

引用

页码：1426 / 1430

页数：5

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