Inhibition of PKR by Viruses

被引：68

作者：

Cesaro, Teresa ^{[1
]}

Michiels, Thomas ^{[1
]}

机构：

[1] Catholic Univ Louvain, de Duve Inst, Brussels, Belgium

来源：

FRONTIERS IN MICROBIOLOGY | 2021年 / 12卷

关键词：

innate immunity; integrated stress response; mRNA translation; innate immunity evasion; viral proteins; double-stranded RNA; DOUBLE-STRANDED-RNA; PROTEIN-KINASE PKR; MESSENGER-RNA; NONSTRUCTURAL PROTEIN; CELLULAR INHIBITOR; STRESS GRANULES; BINDING PROTEIN; COMPLEX-FORMATION; DEPENDENT KINASE; NONCODING RNA;

D O I：

10.3389/fmicb.2021.757238

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cells respond to viral infections through sensors that detect non-self-molecules, and through effectors, which can have direct antiviral activities or adapt cell physiology to limit viral infection and propagation. Eukaryotic translation initiation factor 2 alpha kinase 2, better known as PKR, acts as both a sensor and an effector in the response to viral infections. After sensing double-stranded RNA molecules in infected cells, PKR self-activates and majorly exerts its antiviral function by blocking the translation machinery and inducing apoptosis. The antiviral potency of PKR is emphasized by the number of strategies developed by viruses to antagonize the PKR pathway. In this review, we present an update on the diversity of such strategies, which range from preventing double-stranded RNA recognition upstream from PKR activation, to activating eIF2B downstream from PKR targets.

引用

页数：12

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