Are Beta Blockers New Potential Anticancer Agents?

被引:17
作者
Akbar, Shahid [1 ]
Alsharidah, Mansour Saleh [2 ]
机构
[1] Qassim Univ, Coll Pharm, Dept Pharmacol, Buraydah, Saudi Arabia
[2] Qassim Univ, Coll Med, Dept Physiol, Buraydah, Saudi Arabia
关键词
Beta; blockers; adrenoceptors; anticancer; breast; ovarian; pancreatic; prostate; CONVERTING ENZYME-INHIBITORS; PANCREATIC-CANCER CELLS; ENDOTHELIAL GROWTH-FACTOR; PROMOTES TUMOR-GROWTH; BREAST-CANCER; KAPPA-B; ADRENERGIC-RECEPTORS; CARCINOMA-CELLS; RISK; NOREPINEPHRINE;
D O I
10.7314/APJCP.2014.15.22.9567
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
beta-Blockers have been one of the most widely used and versatile drugs for the past half a century. A new potential for their use as anti-cancer drugs has emerged in the past few years. Various retrospective case control studies have been suggestive that use of beta-blockers before the diagnosis of cancer could have preventive and protective effects against non-small cell lung carcinoma, melanoma, and breast, pancreatic and prostate cancers. Experimental and clinical observations are still inconclusive with some inconsistent findings. However, indications are pointing toward a positive role of some beta-blockers against certain forms of cancers. This mini review is an effort to present the up to date published results of case-control studies and experimental findings.
引用
收藏
页码:9567 / 9574
页数:8
相关论文
共 96 条
[1]   Prevention of pancreatic cancer by the beta-blocker propranolol [J].
Al-Wadei, Hussein A. ;
Al-Wadei, Mohammed H. ;
Schuller, Hildegard M. .
ANTI-CANCER DRUGS, 2009, 20 (06) :477-482
[2]   Is beta-blocker treatment associated with a decrease in the risk of cancer [J].
Algazi, M. ;
Plu-Bureau, G. ;
Flahault, A. ;
Dondon, M-G ;
Le, M. G. .
LETTERS IN DRUG DESIGN & DISCOVERY, 2006, 3 (09) :653-661
[3]   Could treatments with beta-blockers be associated with a reduction in cancer risk? [J].
Algazi, M ;
Plu-Bureau, G ;
Flahault, A ;
Dondon, MG ;
Lê, MG .
REVUE D EPIDEMIOLOGIE ET DE SANTE PUBLIQUE, 2004, 52 (01) :53-65
[4]   Does Beta-blocker Therapy Improve the Survival of Patients with Metastatic Non-small Cell Lung Cancer? [J].
Aydiner, Adnan ;
Ciftci, Rumeysa ;
Karabulut, Senem ;
Kilic, Leyla .
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2013, 14 (10) :6109-6114
[5]   Beta Blockers and Breast Cancer Mortality: A Population-Based Study [J].
Barron, Thomas I. ;
Connolly, Roisin M. ;
Sharp, Linda ;
Bennett, Kathleen ;
Visvanathan, Kala .
JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (19) :2635-2644
[6]   Suppression of NK cell activity and of resistance to metastasis by stress:: A role for adrenal catecholamines and β-adrenoceptors [J].
Ben-Eliyahu, S ;
Shakhar, G ;
Page, GG ;
Stefanski, V ;
Shakhar, K .
NEUROIMMUNOMODULATION, 2000, 8 (03) :154-164
[7]   Perioperative use of β-blockers and COX-2 inhibitors may improve immune competence and reduce the risk of tumor metastasis [J].
Benish, Marganit ;
Bartal, Inbal ;
Goldfarb, Yael ;
Levi, Ben ;
Avraham, Roi ;
Raz, Amiram ;
Ben-Eliyahu, Shamgar .
ANNALS OF SURGICAL ONCOLOGY, 2008, 15 (07) :2042-2052
[8]   Therapeutic effect of β-blockers in triple-negative breast cancer postmenopausal women [J].
Botteri, Edoardo ;
Munzone, Elisabetta ;
Rotmensz, Nicole ;
Cipolla, Carlo ;
De Giorgi, Vincenzo ;
Santillo, Barbara ;
Zanelotti, Arnaldo ;
Adamoli, Laura ;
Colleoni, Marco ;
Viale, Giuseppe ;
Goldhirsch, Aron ;
Gandini, Sara .
BREAST CANCER RESEARCH AND TREATMENT, 2013, 140 (03) :567-575
[9]   Perioperative beta-blocker use and survival in lung cancer patients [J].
Cata, Juan P. ;
Villarreal, John ;
Keerty, Dinesh ;
Thakar, Dilip R. ;
Liu, Diane D. ;
Sood, Anil K. ;
Gottumukkala, Vijaya .
JOURNAL OF CLINICAL ANESTHESIA, 2014, 26 (02) :106-117
[10]   Molecular Pathways: Beta-Adrenergic Signaling in Cancer [J].
Cole, Steven W. ;
Sood, Anil K. .
CLINICAL CANCER RESEARCH, 2012, 18 (05) :1201-1206