The Emerging Neurobiology of Bipolar Disorder

被引：154

作者：

Harrison, Paul J. ^{[1
,2
]}

Geddes, John R. ^{[1
,2
]}

Tunbridge, Elizabeth M. ^{[1
,2
]}

机构：

[1] Univ Oxford, Dept Psychiat, Warneford Hosp, Oxford OX3 7JX, England

[2] Oxford Hlth NHS Fdn Trust, Warneford Hosp, Oxford OX3 7JX, England

来源：

TRENDS IN NEUROSCIENCES | 2018年 / 41卷 / 01期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

GATED CALCIUM-CHANNELS; LOSS-OF-FUNCTION; MOOD INSTABILITY; BORDERLINE PERSONALITY; NEURONAL EXCITABILITY; PSYCHIATRIC DISEASE; RISK; SCHIZOPHRENIA; DEPRESSION; CACNA1C;

D O I：

10.1016/j.tins.2017.10.006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Bipolar disorder (BD) is a leading cause of global disability. Its biological basis is unknown, and its treatment unsatisfactory. Here, we review two recent areas of progress. First, the discovery of risk genes and their implications, with a focus on voltage-gated calcium channels as part of the disease process and as a drug target. Second, facilitated by new technologies, it is increasingly apparent that the bipolar phenotype is more complex and nuanced than simply one of recurring manic and depressive episodes. One such feature is persistent mood instability, and efforts are underway to understand its mechanisms and its therapeutic potential. BD illustrates how psychiatry is being transformed by contemporary neuroscience, genomics, and digital approaches.

引用

页码：18 / 30

页数：13

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