A Recent Survey Confirms the Efficacy and the Safety of Implanted Insulin Pumps During Long-Term Use in Poorly Controlled Type 1 Diabetes Patients

被引:21
作者
Schaepelynck, Pauline [1 ]
Renard, Eric [1 ]
Jeandidier, Nathalie [1 ]
Hanaire, Helene [1 ]
Fermon, Catherine [1 ]
Rudoni, Sabine [1 ]
Catargi, Bogdan [1 ]
Riveline, Jean-Pierre [1 ]
Guerci, Bruno [1 ]
Millot, Luc [1 ]
Martin, Jean-Francois [1 ]
Sola, Agnes [1 ]
机构
[1] CHU Hop Sud, Marseille, France
关键词
BLOOD-GLUCOSE STABILITY; SUBCUTANEOUS INSULIN; GLYCEMIC CONTROL; INTRAPERITONEAL; INFUSION; HBA(1C); LISPRO; IDDM;
D O I
10.1089/dia.2010.0209
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: This article reports a prolonged trial with insulin pumps implanted in patients with type 1 diabetes showing poor glucose control and a high rate of complications. Methods: We reviewed data from 181 patients undergoing implanted insulin pump therapy. Analysis included hemoglobin A1c (HbA1c) values, body weight, and diabetes complications status. Results: At implantation, the mean age was 43 (range, 19-72) years, mean duration of diabetes was 22.2 (2-52) years, and mean body weight was 68.6 (43-104) kg. The complication status involved retinopathy (62% of patients), neuropathy (34.6%), nephropathy (26%), and cardiovascular disease (14%). Patients' previous insulin treatment regimen was multiple daily injections (17.1%) or continuous subcutaneous insulin infusion (82.9%). HbA1c levels significantly dropped from 7.9 +/- 1.2% to 7.6 +/- 1.2% after 1 year (P<0.01) and remained within the range of 7.5-7.6% for up to 5 years. No significant variation of body weight or complications status occurred. Conclusions: Implanted insulin pump therapy demonstrates long-term benefits in type 1 diabetes patients who have poor prognosis under intensive subcutaneous treatment.
引用
收藏
页码:657 / 660
页数:4
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