Steroidal saponins from Trillium tschonoskii rhizomes and their cytotoxicity against HepG2 cells

被引：14

作者：

Yang, Yin-Jun ^{[1
,2
]}

Pang, Xu ^{[1
]}

Wang, Bei ^{[1
]}

Yang, Jie ^{[1
]}

Chen, Xiao-Juan ^{[1
]}

Sun, Xin-Guang ^{[1
]}

Li, Qi ^{[1
]}

Zhang, Jie ^{[1
]}

Guo, Bao-Lin ^{[2
]}

Ma, Bai-ping ^{[1
]}

机构：

[1] Beijing Inst Radiat Med, Beijing 100850, Peoples R China

[2] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Beijing 100193, Peoples R China

来源：

STEROIDS | 2020年 / 156卷

关键词：

Trillium tschonoskii; Liliaceae; Steroidal saponin; Trillitschoside; HepG2; cell; UNDERGROUND PARTS; GLYCOSIDES;

D O I：

10.1016/j.steroids.2020.108587

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A phytochemical study on the rhizomes of Trillium tschonoskii led to the isolation of fourteen new steroidal saponins, trillitschosides S1-514 (1-14), along with ten known analogues (15-24). Their structures were established mainly by spectroscopic analyses as well as necessary chemical evidence. All isolated compounds were screened for the cytotoxicity against HepG2 cells, and the results demonstrated that only the known compounds 21-24 exhibited the remarkable cytotoxic activity against HepG2 cells which is much better than the positive control of 5-FU.

引用

页数：7

共 50 条

[41] The Impact of Zinc on Manganese Bioavailability and Cytotoxicity in HepG2 Cells [J].

Michaelis, Vivien ;

Kasper, Silja ;

Naperkowski, Lisa ;

Pusse, Jan ;

Thiel, Alicia ;

Ebert, Franziska ;

Aschner, Michael ;

Schwerdtle, Tanja ;

Haase, Hajo ;

Bornhorst, Julia .

MOLECULAR NUTRITION & FOOD RESEARCH, 2023, 67 (06)

[42] Cytotoxicity and apoptosis-inducing effect of steroidal saponins from Dioscorea zingiberensis Wright against cancer cells [J].

Tong, Qing-Yi ;

He, Yang ;

Zhao, Qing-Bing ;

Qing, Yong ;

Huang, Wen ;

Wu, Xiao-Hua .

STEROIDS, 2012, 77 (12) :1219-1227

[43] Steroidal saponins from the rhizomes of Hosta sieboldii and their cytostatic activity on HL-60 cells [J].

Mimaki, Y ;

Kuroda, M ;

Kameyama, A ;

Yokosuka, A ;

Sashida, Y .

PHYTOCHEMISTRY, 1998, 48 (08) :1361-1369

[44] Cytotoxicity and antihyperglycemic effect of minor constituents from Rhizoma Coptis in HepG2 cells [J].

Chen, Hong-Ying ;

Ye, Xiao-Li ;

Cui, Xue-Long ;

He, Kai ;

Jin, Ya-Nan ;

Chen, Zhu ;

Li, Xue-Gang .

FITOTERAPIA, 2012, 83 (01) :67-73

[45] Cytotoxicity of compounds from the fruits of Derris indica against cholangiocarcinoma and HepG2 cell lines [J].

Decharchoochart, Phatharapoll ;

Suthiwong, Jittra ;

Samatiwat, Papavee ;

Kukongviriyapan, Veerapol ;

Yenjai, Chavi .

JOURNAL OF NATURAL MEDICINES, 2014, 68 (04) :730-736

[46] Cytotoxicity of compounds from the fruits of Derris indica against cholangiocarcinoma and HepG2 cell lines [J].

Phatharapoll Decharchoochart ;

Jittra Suthiwong ;

Papavee Samatiwat ;

Veerapol Kukongviriyapan ;

Chavi Yenjai .

Journal of Natural Medicines, 2014, 68 :730-736

[47] Cytotoxicity against cholangiocarcinoma and HepG2 cell lines of lignan derivatives from Hernandia nymphaeifolia [J].

Jittra Suthiwong ;

Jaroon Wandee ;

Siripit Pitchuanchom ;

Punchapat Sojikul ;

Veerapol Kukongviriyapan ;

Chavi Yenjai .

Medicinal Chemistry Research, 2018, 27 :2042-2049

[48] Cytotoxicity against cholangiocarcinoma and HepG2 cell lines of lignan derivatives from Hernandia nymphaeifolia [J].

Suthiwong, Jittra ;

Wandee, Jaroon ;

Pitchuanchom, Siripit ;

Sojikul, Punchapat ;

Kukongviriyapan, Veerapol ;

Yenjai, Chavi .

MEDICINAL CHEMISTRY RESEARCH, 2018, 27 (08) :2042-2049

[49] NEW STEROIDAL SAPONINS FROM THE RHIZOMES OF ANEMARRHENA ASPHODELOIDES BUNGE (LILIACEAE) [J].

SAITO, S ;

NAGASE, S ;

ICHINOSE, K .

CHEMICAL & PHARMACEUTICAL BULLETIN, 1994, 42 (11) :2342-2345

[50] Protective effects of betulin and betulinic acid against ethanol-induced cytotoxicity in HepG2 cells [J].

Szuster-Ciesielska, A ;

Kandefer-Szerszen, M .

PHARMACOLOGICAL REPORTS, 2005, 57 (05) :588-595

← 1 2 3 4 5 →