Steroidal saponins from Trillium tschonoskii rhizomes and their cytotoxicity against HepG2 cells

被引：14

作者：

Yang, Yin-Jun ^{[1
,2
]}

Pang, Xu ^{[1
]}

Wang, Bei ^{[1
]}

Yang, Jie ^{[1
]}

Chen, Xiao-Juan ^{[1
]}

Sun, Xin-Guang ^{[1
]}

Li, Qi ^{[1
]}

Zhang, Jie ^{[1
]}

Guo, Bao-Lin ^{[2
]}

Ma, Bai-ping ^{[1
]}

机构：

[1] Beijing Inst Radiat Med, Beijing 100850, Peoples R China

[2] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Beijing 100193, Peoples R China

来源：

STEROIDS | 2020年 / 156卷

关键词：

Trillium tschonoskii; Liliaceae; Steroidal saponin; Trillitschoside; HepG2; cell; UNDERGROUND PARTS; GLYCOSIDES;

D O I：

10.1016/j.steroids.2020.108587

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A phytochemical study on the rhizomes of Trillium tschonoskii led to the isolation of fourteen new steroidal saponins, trillitschosides S1-514 (1-14), along with ten known analogues (15-24). Their structures were established mainly by spectroscopic analyses as well as necessary chemical evidence. All isolated compounds were screened for the cytotoxicity against HepG2 cells, and the results demonstrated that only the known compounds 21-24 exhibited the remarkable cytotoxic activity against HepG2 cells which is much better than the positive control of 5-FU.

引用

页数：7

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[31] Cytotoxic Steroidal Saponins from the Rhizomes of Tacca integrifolia [J].

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Reiser, Oliver ;

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[32] STEROIDAL SAPONINS FROM THE RHIZOMES OF SMILAX-SIEBOLDII [J].

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[39] Rapid Identification of Steroidal Saponins in Trillium Tschonoskii Maxim by Ultraperformance Liquid Chromatography Coupled to Electrospray Ionisation Quadrupole Time-of-Flight Tandem Mass Spectrometry [J].

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